Salama Basem, Tharwat Elbakry M
Community Medicine Department, Damietta Faculty of Medicine, Al-Azhar University, Egypt.
Department of Family and Community Medicine, Faculty of Medicine, Northern Border University, Saudi Arabia.
J Public Health Res. 2023 Jan 25;12(1):22799036221150557. doi: 10.1177/22799036221150557. eCollection 2023 Jan.
Neonatal Sepsis is a significant leading cause of infant death around the world, particularly in developing nations. The study aimed to identify maternal and neonatal risk factors linked to neonatal sepsis.
A hospital-based case-control study was conducted in the ICU. Cases were neonates diagnosed as having sepsis by clinical criteria and laboratory findings. Controls were admitted neonates who were neither suspected nor diagnosed with sepsis. Data on mothers and babies, as well as laboratory findings, were gathered and analyzed.
A total of 174 cases and 348 controls were included in the study. Maternal age, parity, route of delivery, PROM, prematurity, birth weight, neonatal gender and age were significantly associated with the risk of sepsis ( < 0.05). However, the bivariate logistic model revealed that the most influential predictors of neonatal sepsis were premature rupture of membranes, Gestational age, Neonatal age, birth weight, and mode of delivery.
Both maternal and neonatal variables were found to have a significant association with the risk of neonatal sepsis; thus, empowering mothers to pursue antenatal care may allow the detection of risk factors for undesirable delivery consequences such as neonatal sepsis, as well as appropriate management to mitigate those risks.
新生儿败血症是全球婴儿死亡的一个重要主要原因，尤其是在发展中国家。该研究旨在确定与新生儿败血症相关的孕产妇和新生儿风险因素。
在重症监护病房进行了一项基于医院的病例对照研究。病例为根据临床标准和实验室检查结果诊断为败血症的新生儿。对照为既未被怀疑也未被诊断为败血症的入院新生儿。收集并分析了有关母亲和婴儿的数据以及实验室检查结果。
该研究共纳入174例病例和348例对照。产妇年龄、产次、分娩方式、胎膜早破、早产、出生体重、新生儿性别和年龄与败血症风险显著相关（<0.05）。然而，二元逻辑模型显示，新生儿败血症最有影响力的预测因素是胎膜早破、孕周、新生儿年龄、出生体重和分娩方式。
发现孕产妇和新生儿变量均与新生儿败血症风险存在显著关联；因此，使母亲有能力获得产前护理可能有助于发现诸如新生儿败血症等不良分娩后果的风险因素，以及进行适当管理以降低这些风险。
