Lose G, Sørensen K, Frandsen B, Nathan E
Department of Surgery D, University of Copenhagen, Denmark.
Urol Res. 1987;15(4):249-50. doi: 10.1007/BF00262110.
Tamm-Horsfall glycoprotein (THG) might constitute a bacteria-fixing mucus which contributes to the non-immunological anti-infectious mechanisms of the lower urinary tract. To evaluate the role of THG in girls with idiopathic recurrent lower urinary tract infections, the THG excretion and concentration in 24-h urine were measured by a radial immunodiffusion method in 16 patients with a median age of 9 years and in 14 healthy age-matched girls. The results showed no significant differences in the THG excretion or concentration between the patients and the controls. Transiently decreased THG excretion rates as well as functional changes in the ability and/or capacity to trap bacteria, however, may leave girls periodically prone to colonization of the bladder. Thus, further studies are warranted to evaluate the importance of THG in the bladder defence mechanism.
Tamm-Horsfall糖蛋白（THG）可能构成一种固定细菌的黏液，它有助于下尿路的非免疫抗感染机制。为了评估THG在患有特发性复发性下尿路感染的女孩中的作用，采用放射免疫扩散法测量了16名中位年龄为9岁的患者以及14名年龄匹配的健康女孩24小时尿液中的THG排泄量和浓度。结果显示，患者与对照组之间的THG排泄量或浓度无显著差异。然而，THG排泄率的短暂下降以及捕获细菌能力和/或容量的功能变化，可能会使女孩周期性地易于膀胱定植。因此，有必要进一步研究以评估THG在膀胱防御机制中的重要性。
