Department of Basic Biology, Changsha Medical University, Changsha, China.
Center for Neuroscience and Behavior, Changsha Medical University, Changsha, China.
Biomed Res Int. 2023 Jan 23;2023:1235552. doi: 10.1155/2023/1235552. eCollection 2023.
Vascular dementia (VaD) is the second most prevalent dementia, which is attributable to neurovascular dysfunction. Currently, no approved pharmaceuticals are available. Taohong Siwu decoction (TSD) is a traditional Chinese medicine prescription with powerful antiapoptosis and anti-inflammatory properties. In this study, a network pharmacology approach together with molecular docking validation was used to explore the probable mechanism of action of TSD against VaD. A total of 44 active components, 202 potential targets of components, and 3,613 VaD-related targets including 161 intersecting were obtained. The potential chemical components including kaempferol, baicalein, beta-carotene, luteolin, quercetin, and beta-sitosterol involved in the inflammatory response, oxidative stress, and apoptosis might have potential therapeutic effects on the treatment of VaD. The potential core targets including AKT1, CASP3, IL1, JUN, and TP53 associated with cell apoptosis and inflammatory might account for the essential therapeutic effects of TSD in VaD. The results indicated that TSD protected against VaD through multicomponent and multitarget modes. Though the detailed mechanism of action of various active ingredients needs to be further illustrated, TSD still showed a promising therapeutic agent for VaD due to its biological activity.
血管性痴呆（VaD）是第二大常见的痴呆症，其归因于神经血管功能障碍。目前，尚无批准的药物。桃红四物汤（TSD）是一种具有强大抗凋亡和抗炎作用的中药方剂。在这项研究中，采用网络药理学方法结合分子对接验证，探讨 TSD 治疗 VaD 的可能作用机制。共获得 44 个活性成分、202 个成分的潜在靶点和 3613 个 VaD 相关靶点，包括 161 个相交靶点。涉及炎症反应、氧化应激和细胞凋亡的潜在化学成分，如山奈酚、黄芩素、β-胡萝卜素、木犀草素、槲皮素和β-谷甾醇，可能对治疗 VaD 具有潜在的治疗作用。与细胞凋亡和炎症相关的潜在核心靶点，如 AKT1、CASP3、IL1、JUN 和 TP53，可能是 TSD 在 VaD 中发挥重要治疗作用的原因。结果表明，TSD 通过多成分和多靶点模式来预防 VaD。尽管各种活性成分的详细作用机制需要进一步阐明，但由于其生物活性，TSD 仍然显示出对 VaD 有希望的治疗剂。
