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在中国内地大型医院,导航下髓内钉固定术治疗股骨转子间骨折具有成本效益:一项马尔可夫决策分析。

Navigated intramedullary nailing for patients with intertrochanteric hip fractures is cost-effective at high-volume hospitals in mainland China: A markov decision analysis.

作者信息

Tang Liang, Yi Xiaoke, Yuan Ting, Li Hua, Xu Cheng

机构信息

Department of Orthopaedics, Hengyang Central Hospital, The Affiliated Hengyang Hospital of Southern Medical University, Hengyang, China.

Senior Department of Orthopaedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.

出版信息

Front Surg. 2023 Jan 16;9:1048885. doi: 10.3389/fsurg.2022.1048885. eCollection 2022.

Abstract

OBJECTIVE

Previous studies have reported that navigation systems can improve clinical outcomes of intramedullary nailing (IMN) for patients with intertrochanteric fractures. However, information is lacking regarding the relationship between the costs of navigated systems and clinical outcomes. The present research aimed to evaluate the cost-effectiveness of navigated IMN as compared with traditional freehand IMN for patients with intertrochanteric fractures.

METHODS

A Markov decision model with a 5-year time horizon was constructed to investigate the costs, clinical outcomes and incremental cost-effectiveness ratio (ICER) of navigated IMN for a 70-year-old patient with an intertrochanteric fracture in mainland China. The costs [Chinese Yuan (¥)], health utilities (quality-adjusted life-years, QALYs) and transition probabilities were obtained from published studies. The willingness-to-pay threshold for ICER was set at ¥1,40,000/QALY following the Chinese gross domestic product in 2020. Three institutional surgical volumes were used to determine the average navigation-related costs per patient: low volume (100 cases), medium volume (200 cases) and high volume (300 cases).

RESULTS

Institutes at which 300, 200 and 100 cases of navigated IMN were performed per year showed an ICER of ¥43,149/QALY, ¥76,132.5/QALY and ¥1,75,083/QALY, respectively. Navigated IMN would achieve cost-effectiveness at institutes with an annual volume of more than 125 cases.

CONCLUSIONS

Our analysis demonstrated that the navigated IMN could be cost-effective for patients with inter-trochanteric fracture as compared to traditional freehand IMN. However, the cost-effectiveness was more likely to be achieved at institutes with a higher surgical volume.

摘要

目的

既往研究报道,导航系统可改善转子间骨折患者髓内钉固定(IMN)的临床疗效。然而,关于导航系统成本与临床疗效之间的关系,目前尚缺乏相关信息。本研究旨在评估与传统徒手IMN相比,导航IMN用于转子间骨折患者的成本效益。

方法

构建一个为期5年的马尔可夫决策模型,以研究中国大陆一名70岁转子间骨折患者接受导航IMN的成本、临床疗效和增量成本效益比(ICER)。成本(人民币)、健康效用(质量调整生命年,QALYs)和转移概率均来自已发表的研究。根据2020年中国国内生产总值,将ICER的支付意愿阈值设定为140,000元/QALY。采用三个机构的手术量来确定每位患者的平均导航相关成本:低手术量(100例)、中等手术量(200例)和高手术量(300例)。

结果

每年进行300例、200例和100例导航IMN手术的机构,其ICER分别为43,149元/QALY、76,132.5元/QALY和175,083元/QALY。每年手术量超过125例的机构,导航IMN将实现成本效益。

结论

我们的分析表明,与传统徒手IMN相比,导航IMN对于转子间骨折患者可能具有成本效益。然而,手术量较高的机构更有可能实现成本效益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ce/9885142/d77307863c95/fsurg-09-1048885-g001.jpg

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