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中国大陆非移位型股骨颈骨折半髋关节置换术与内固定术的成本效益分析

Hemiarthroplasty vs. internal fixation for nondisplaced femoral neck fracture in mainland China: a cost-effectiveness analysis.

作者信息

Wang Shengchun, Tan Lingjie, Sheng Bin

机构信息

Department of Orthopaedics, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.

出版信息

Front Surg. 2024 Aug 29;11:1437290. doi: 10.3389/fsurg.2024.1437290. eCollection 2024.

Abstract

OBJECTIVE

Nondisplaced femoral neck fractures constitute a substantial portion of these injuries. The optimal treatment strategy between internal fixation (IF) and hemiarthroplasty (HA) remains debated, particularly concerning cost-effectiveness.

METHODS

We conducted a cost-effectiveness analysis using a Markov decision model to compare HA and IF in treating nondisplaced femoral neck fractures in elderly patients in China. The analysis was performed from a payer perspective with a 5-year time horizon. Costs were measured in 2020 USD, and effectiveness was measured in quality-adjusted life-years (QALYs). Sensitivity analyses, including one-way and probabilistic analyses, were conducted to assess the robustness of the results. The willingness-to-pay threshold for incremental cost-effectiveness ratio (ICER) was set at $11,083/QALY following the Chinese gross domestic product in 2020.

RESULTS

HA demonstrated higher cumulative QALYs (2.94) compared to IF (2.75) but at a higher total cost ($13,324 vs. $12,167), resulting in an ICER of $6,128.52/QALY. The one-way sensitivity analysis identified the costs of HA and IF as the most influential factors. Probabilistic sensitivity analysis indicated that HA was more effective in 69.3% of simulations, with an ICER below the willingness-to-pay threshold of $11,083 in 58.8% of simulations.

CONCLUSIONS

HA is a cost-effective alternative to IF for treating nondisplaced femoral neck fractures in elderly patients in mainland China.

摘要

目的

无移位股骨颈骨折在这类损伤中占相当大的比例。内固定(IF)和半髋关节置换术(HA)之间的最佳治疗策略仍存在争议,尤其是在成本效益方面。

方法

我们使用马尔可夫决策模型进行成本效益分析,以比较HA和IF在中国老年患者无移位股骨颈骨折治疗中的效果。该分析从支付方的角度进行,时间跨度为5年。成本以2020年美元计量,效果以质量调整生命年(QALYs)计量。进行了敏感性分析,包括单因素分析和概率分析,以评估结果的稳健性。根据2020年中国国内生产总值,将增量成本效益比(ICER)的支付意愿阈值设定为11,083美元/QALY。

结果

与IF(2.75)相比,HA显示出更高的累积QALYs(2.94),但总成本更高(13,324美元对12,167美元),导致ICER为6,128.52美元/QALY。单因素敏感性分析确定HA和IF的成本是最有影响的因素。概率敏感性分析表明,在69.3%的模拟中HA更有效,在58.8%的模拟中ICER低于11,083美元的支付意愿阈值。

结论

对于中国大陆老年患者无移位股骨颈骨折的治疗,HA是一种比IF更具成本效益的替代方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f20/11391527/2847e05f0da9/fsurg-11-1437290-g001.jpg

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