Wang Shengchun, Tan Lingjie, Sheng Bin
Department of Orthopaedics, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
Front Surg. 2024 Aug 29;11:1437290. doi: 10.3389/fsurg.2024.1437290. eCollection 2024.
Nondisplaced femoral neck fractures constitute a substantial portion of these injuries. The optimal treatment strategy between internal fixation (IF) and hemiarthroplasty (HA) remains debated, particularly concerning cost-effectiveness.
We conducted a cost-effectiveness analysis using a Markov decision model to compare HA and IF in treating nondisplaced femoral neck fractures in elderly patients in China. The analysis was performed from a payer perspective with a 5-year time horizon. Costs were measured in 2020 USD, and effectiveness was measured in quality-adjusted life-years (QALYs). Sensitivity analyses, including one-way and probabilistic analyses, were conducted to assess the robustness of the results. The willingness-to-pay threshold for incremental cost-effectiveness ratio (ICER) was set at $11,083/QALY following the Chinese gross domestic product in 2020.
HA demonstrated higher cumulative QALYs (2.94) compared to IF (2.75) but at a higher total cost ($13,324 vs. $12,167), resulting in an ICER of $6,128.52/QALY. The one-way sensitivity analysis identified the costs of HA and IF as the most influential factors. Probabilistic sensitivity analysis indicated that HA was more effective in 69.3% of simulations, with an ICER below the willingness-to-pay threshold of $11,083 in 58.8% of simulations.
HA is a cost-effective alternative to IF for treating nondisplaced femoral neck fractures in elderly patients in mainland China.
无移位股骨颈骨折在这类损伤中占相当大的比例。内固定(IF)和半髋关节置换术(HA)之间的最佳治疗策略仍存在争议,尤其是在成本效益方面。
我们使用马尔可夫决策模型进行成本效益分析,以比较HA和IF在中国老年患者无移位股骨颈骨折治疗中的效果。该分析从支付方的角度进行,时间跨度为5年。成本以2020年美元计量,效果以质量调整生命年(QALYs)计量。进行了敏感性分析,包括单因素分析和概率分析,以评估结果的稳健性。根据2020年中国国内生产总值,将增量成本效益比(ICER)的支付意愿阈值设定为11,083美元/QALY。
与IF(2.75)相比,HA显示出更高的累积QALYs(2.94),但总成本更高(13,324美元对12,167美元),导致ICER为6,128.52美元/QALY。单因素敏感性分析确定HA和IF的成本是最有影响的因素。概率敏感性分析表明,在69.3%的模拟中HA更有效,在58.8%的模拟中ICER低于11,083美元的支付意愿阈值。
对于中国大陆老年患者无移位股骨颈骨折的治疗,HA是一种比IF更具成本效益的替代方案。