Li Xinyu, Wang Jiaqi, Zhang Jinyu, Zhang Nan, Wu Caiqin, Geng Zhaohui, Zhou Jie, Dong Lu
Author Affiliations: School of Nursing, Shanghai University of Traditional Chinese Medicine, Shanghai, China (Ms Li, Mr Wang, and Drs Zhang, Wu, Geng, Zhou, and Dong); and Department of Breast Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (Ms N Zhang).
Cancer Nurs. 2023 Jan 16. doi: 10.1097/NCC.0000000000001196.
Chemotherapy is a primary adjuvant treatment strategy for breast cancer patients, accompanied by weight gain and negative changes in body composition. However, it is unknown whether exercise is effective in preventing said weight gain and mitigating body composition changes of breast cancer patients undergoing treatment.
The current study used meta-analysis with trial sequential analysis to determine exercise effect on weight and body composition of breast cancer patients undergoing chemotherapy.
Cochrane Library, PubMed, EMBASE, EBSCO, Scopus, and SinoMed were searched (from the database start date up to August 16, 2021) for randomized controlled studies evaluating the effect of exercise on weight or body composition among breast cancer patients during chemotherapy. RevMan software and TSA Software were used to assess the risk of bias and analyze study results.
In total, 13 studies comprising 1828 participants were included. Meta-analysis showed that exercise could lead to lower weight, body mass index (BMI), and percentage of body fat during chemotherapy for breast cancer patients, and muscular strength showed significant improvement. Trial sequential analysis showed that evidence of muscular strength was sufficient, but BMI evidence requires further confirmation.
This meta-analysis found significant differences in body weight, BMI, percentage of body fat, and muscular strength between exercise intervention groups and control groups.
Exercise during chemotherapy is beneficial in preventing weight gain and negative changes in body composition. Medical practitioners should encourage patients to start exercising during chemotherapy. However, further studies are required because insufficient sample sizes meant that outcomes of body composition remain unconfirmed.
化疗是乳腺癌患者的主要辅助治疗策略，但会伴随体重增加和身体成分的负面变化。然而，运动对于预防接受治疗的乳腺癌患者体重增加和减轻身体成分变化是否有效尚不清楚。
本研究采用荟萃分析和试验序贯分析来确定运动对接受化疗的乳腺癌患者体重和身体成分的影响。
检索Cochrane图书馆、PubMed、EMBASE、EBSCO、Scopus和中国生物医学文献数据库（从各数据库起始日期至2021年8月16日），查找评估运动对乳腺癌患者化疗期间体重或身体成分影响的随机对照研究。使用RevMan软件和TSA软件评估偏倚风险并分析研究结果。
共纳入13项研究，1828名参与者。荟萃分析表明，运动可使乳腺癌患者化疗期间体重、体重指数（BMI）和体脂百分比降低，肌肉力量有显著改善。试验序贯分析表明，肌肉力量的证据充分，但BMI的证据需要进一步证实。
本荟萃分析发现运动干预组与对照组在体重、BMI、体脂百分比和肌肉力量方面存在显著差异。
化疗期间运动有助于预防体重增加和身体成分的负面变化。医生应鼓励患者在化疗期间开始运动。然而，由于样本量不足，身体成分的结果仍未得到证实，因此需要进一步研究。
