奥替拉酮 A 对四氯化碳诱导的小鼠肝毒性的双重治疗潜力。
The Dual Therapeutic Potential of Ottelione A on Carbon Tetrachloride-induced Hepatic Toxicity in Mice.
机构信息
Biochemistry division, Chemistry Department, Faculty of Science, Damietta University, 34517, Damietta, New-Damietta, Egypt.
Departments of Chemistry and Medicinal Chemistry, University of Minnesota, 55455, Minneapolis, MN, USA.
出版信息
Appl Biochem Biotechnol. 2023 Oct;195(10):5966-5979. doi: 10.1007/s12010-023-04346-8. Epub 2023 Feb 2.
BACKGROUND
Some herbal natural products play an important role in protecting organisms from the toxic effect of some xenobiotics. The present study was designed to evaluate the potential therapeutic effects of Ottelione A (OTTE) against carbon tetrachloride(CCl)-induced toxicity in mice.
METHODS
Adult male Swiss albino mice were divided into six groups: group I was used as a normal control received olive oil; group II received DMSO; group III received OTTE; group IV received CCl in olive oil, (injected i.p) 3 times/week for 6 weeks; group V received the same CCl regimen as group IV followed by OTTE injected for 15 days, and group VI first received OTTE injected for 15 days followed by the same CCl regimen as group IV. Some biochemical and histological parameters were investigated.
RESULTS
Our results showed that the administration of CCl caused hepatotoxicity, as monitored by the significant increase in biochemical parameters concerning the olive oil group. Treatment with OTTE appeare d to be effective against hepatotoxic and liver changes induced by CCl, as evidenced by the improvement of the same parameters.
CONCLUSION
Ottelione A (OTTE) has good antioxidant and therapeutic properties, which can help in preventing CCl-induced hepatotoxicity in both pre-treatment and post-treatment modes.
背景
一些草药天然产物在保护生物免受某些外源性毒物的毒性作用方面发挥着重要作用。本研究旨在评估 Ottelione A（OTTE）对四氯化碳（CCl）诱导的小鼠毒性的潜在治疗作用。
方法
将成年雄性瑞士白化病小鼠分为六组：第 I 组作为正常对照，给予橄榄油；第 II 组给予 DMSO；第 III 组给予 OTTE；第 IV 组给予橄榄油中的 CCl，每周腹腔注射 3 次，共 6 周；第 V 组给予与第 IV 组相同的 CCl 方案，随后给予 OTTE 注射 15 天；第 VI 组先给予 OTTE 注射 15 天，然后给予与第 IV 组相同的 CCl 方案。研究了一些生化和组织学参数。
结果
我们的结果表明，CCl 的给药导致肝毒性，这可以通过与橄榄油组相比，生化参数的显著增加来监测。OTTE 的治疗似乎对 CCl 诱导的肝毒性和肝变化有效，这可以通过改善相同参数来证明。
结论
Ottelione A（OTTE）具有良好的抗氧化和治疗特性，可帮助预防 CCl 诱导的肝毒性，无论是预处理还是后处理模式。
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