Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Cancer Lett. 2023 Mar 31;557:216077. doi: 10.1016/j.canlet.2023.216077. Epub 2023 Jan 30.
At the moment, anaplastic changes within the brain are challenging due to the complexity of neural tissue, leading to the inefficiency of therapeutic protocols. The existence of a cellular interface, namely the blood-brain barrier (BBB), restricts the entry of several macromolecules and therapeutic agents into the brain. To date, several nano-based platforms have been used in laboratory settings and in vivo conditions to overcome the barrier properties of BBB. Exosomes (Exos) are one-of-a-kind of extracellular vesicles with specific cargo to modulate cell bioactivities in a paracrine manner. Regarding unique physicochemical properties and easy access to various biofluids, Exos provide a favorable platform for drug delivery and therapeutic purposes. Emerging data have indicated that Exos enable brain penetration of selective cargos such as bioactive factors and chemotherapeutic compounds. Along with these statements, the application of smart delivery approaches can increase delivery efficiency and thus therapeutic outcomes. Here, we highlighted the recent advances in the application of Exos in the context of brain tumors.
目前，由于神经组织的复杂性，大脑中的间变改变具有挑战性，导致治疗方案效率低下。细胞界面（即血脑屏障（BBB））的存在限制了许多大分子和治疗剂进入大脑。迄今为止，已经有几种基于纳米的平台在实验室环境和体内条件下被用于克服 BBB 的屏障特性。外泌体（Exos）是一种独特的细胞外囊泡，具有特定的货物，以旁分泌的方式调节细胞的生物活性。鉴于独特的物理化学性质和易于获得各种生物流体，Exos 为药物输送和治疗目的提供了有利的平台。新出现的数据表明，Exos 能够使选择性货物（如生物活性因子和化疗化合物）穿透大脑。除此之外，智能递药方法的应用可以提高递药效率，从而改善治疗效果。在这里，我们强调了 Exos 在脑肿瘤方面的应用的最新进展。
