Lu Ping-Hsun, Lai Chien-Cheng, Chiu Ling-Ya, Wang Jen-Yu, Lu Po-Hsuan
Department of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan.
Front Pharmacol. 2023 Jan 17;14:1064926. doi: 10.3389/fphar.2023.1064926. eCollection 2023.
Uremic pruritus is common in dialysis patients and reduces their quality of life. Chinese herbal medicine has been effective in patients with this condition. We conducted a random-effects network meta-analysis to compare the efficacies of different Chinese herbal medicine treatments for uremic pruritus. Outcome measures including the overall effective rates, visual analog scale scores, C-reactive protein levels, and adverse drug reactions were analyzed. The network meta-analysis retrieved 25 randomized controlled trials. Compared with conventional treatments alone, combination treatments with Xiao-Yang-Ke-Li was the most effective intervention in decreasing visual analog scale scores (mean difference -2.98, 95% mean difference -5.05 to -0.91) and levels of C-reactive protein (mean difference -5.01, 95% mean difference -7.27 to -2.75). Conventional treatment combined with Si-Wu Tang was superior to other therapeutic combinations when overall effective rates were determined. The best visual analog scale scores and overall effective rates were achieved by adjunctive treatment with the Touxie-Jiedu-Zhiyang decoction followed by uremic clearance granules; these treatments were the most beneficial for uremic pruritis. Our network meta-analysis provided the relative efficacies of different adjunctive Chinese herbal formulas. Adjunctive treatment with the Touxie-Jiedu-Zhiyang decoction was the best treatment for improving overall effective rates and reducing visual analog scores of uremic pruritus in dialysis patients. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=357656; Identifier: CRD42022357656.
尿毒症瘙痒在透析患者中很常见，会降低他们的生活质量。中药对患有这种病症的患者有效。我们进行了一项随机效应网络荟萃分析，以比较不同中药治疗尿毒症瘙痒的疗效。分析了包括总有效率、视觉模拟量表评分、C反应蛋白水平和药物不良反应在内的结局指标。该网络荟萃分析检索到25项随机对照试验。与单纯的传统治疗相比，消痒颗粒联合治疗在降低视觉模拟量表评分（平均差-2.98，95%平均差-5.05至-0.91）和C反应蛋白水平（平均差-5.01，95%平均差-7.27至-2.75）方面是最有效的干预措施。在确定总有效率时，传统治疗联合四物汤优于其他治疗组合。透邪解毒止痒汤联合尿毒症清颗粒辅助治疗的视觉模拟量表评分和总有效率最佳；这些治疗对尿毒症瘙痒最有益。我们的网络荟萃分析提供了不同辅助中药配方的相对疗效。透邪解毒止痒汤辅助治疗是提高透析患者尿毒症瘙痒总有效率和降低视觉模拟评分的最佳治疗方法。https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=357656；标识符：CRD42022357656 。
