Liu Wen-Tao, Yang Zhi-Chao, Wang Xiao-Hui, Yang Yuan-Jiao, Liu Chen, Yan Han-Bing, Zhang Ya-Nan, Wang Jun, He Hui
Clinical Research Center, Liaoning Province Benxi Central Hospital, Benxi, Liaoning, 117000, People's Republic of China.
Department of Research and Development, Liaoning Province Benxi Clinical Bio-Bank, Benxi, Liaoning, 117000, People's Republic of China.
Int J Gen Med. 2025 May 26;18:2715-2725. doi: 10.2147/IJGM.S512339. eCollection 2025.
This study aimed to assess the risk factors for acute first-ever ischaemic stroke (IS) in the elderly population aged ≥60 years in the eastern part of Liaoning Province, China.
This retrospective case-control study was derived from the Benxi Clinical Biobank and the Thrombotic Chronic Non-Communicable Disease Cohort Study in Natural Populations in Eastern Liaoning (ChiCTR2300074593). We collected cases of acute IS in the elderly population and selected the corresponding controls in a 1:1 ratio for inclusion in the study. Data collection included sociodemographics, clinical characteristics, and laboratory characteristics. We used IBM SPSS Statistics V26.0 for Windows for descriptive statistical analysis and conditional logistic regression analysis to determine risk factors for IS.
This study included 326 cases (163 pairs) of study subjects. The median age of the cases and controls was 65 years (62-70). Both groups were predominantly 60-69 years old in the age subgroups, 69.3% in the case group and 74.2% in the control group, with a p-value of 0.011; females in both groups accounted for 49.1% in the case group and 49.1% in the control group. Variables with P < 0.05 in the univariate analysis included current smoking, current alcohol consumption, fasting blood glucose, and hypertension. Variables statistically significant in the univariate analysis entered into the multivariate multifactorial analysis. The results showed that hypertension (OR, 1.977; 95% CI, 1.322-2.956) and current alcohol consumption (OR, 1.549; 95% CI, 1.086-2.210) were independent risk factors for acute first-ever IS in the elderly population aged ≥60 years.
Hypertension and current alcohol consumption are major risk factors for IS in an elderly population in eastern Liaoning Province.
本研究旨在评估中国辽宁省东部≥60岁老年人群首次急性缺血性卒中（IS）的危险因素。
本回顾性病例对照研究源自本溪临床生物样本库和辽东地区自然人群血栓性慢性非传染性疾病队列研究（ChiCTR2300074593）。我们收集了老年人群急性IS病例，并按1:1比例选取相应对照纳入研究。数据收集包括社会人口统计学、临床特征和实验室特征。我们使用IBM SPSS Statistics V26.0 for Windows进行描述性统计分析和条件逻辑回归分析，以确定IS的危险因素。
本研究纳入326例（163对）研究对象。病例组和对照组的中位年龄为65岁（62 - 70岁）。在年龄亚组中，两组主要为60 - 69岁，病例组占69.3%，对照组占74.2%，p值为0.011；两组女性比例在病例组和对照组均为49.1%。单因素分析中P < 0.05的变量包括当前吸烟、当前饮酒、空腹血糖和高血压。单因素分析中有统计学意义的变量纳入多因素多变量分析。结果显示，高血压（OR，1.977；95%CI，1.322 - 2.956）和当前饮酒（OR，1.549；95%CI，1.086 - 2.210）是≥60岁老年人群首次急性IS的独立危险因素。
高血压和当前饮酒是辽东地区老年人群IS的主要危险因素。
