Uranova N A, Levité O I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1987;87(7):1017-24.
The compact portion of the substantia nigra containing dopamine neurons was studied at autopsy in schizophrenics and in a control group. Neurons presented pathological inclusions composed of electron dense material in the form of parallel rows of microstructures which were not observed in the control. It is postulated that they originate from microtubules in neuronal bodies and neurofilaments in neuronal processes. The authors revealed dystrophic-destructive changes in axon terminals in synapses on spikes, dendrites of variable diameters and the neuronal soma with hyperproduction of the membranous structures and reduction in the size of the active zone of synapses. Membranous structures were also detected both inside and outside myelin fibers. The data obtained are suggestive of a peculiar dystrophic process in neurons related probably to protein metabolic disorder and dystrophic-destructive changes in afferent systems of one of the dopamine areas of the brain.
在尸检中对精神分裂症患者和对照组中含有多巴胺神经元的黑质致密部进行了研究。神经元呈现出由电子致密物质构成的病理性包涵体，其形式为平行排列的微结构行，而在对照组中未观察到。据推测，它们起源于神经元胞体中的微管和神经元突起中的神经丝。作者揭示了突触后电位上的轴突终末、不同直径的树突以及神经元胞体中存在营养不良性破坏变化，伴有膜性结构的过度产生和突触活性区大小的减小。在髓鞘纤维内外也检测到了膜性结构。所获得的数据提示神经元中存在一种特殊的营养不良过程，这可能与蛋白质代谢紊乱以及大脑多巴胺区域之一的传入系统中的营养不良性破坏变化有关。
