Uranova N A, Aganova E A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1989;89(7):56-9.
Autopsied anterior limbic cortex (field 24) was investigated in order to provide an electron microscopic characterization of spine and dendrite synapses. Major changes of synapses were detected in I-II layers of anterior limbic cortex. Heterogeneity of axon terminals increased as the active zone increased in length. In a part of synapses terminal swelling was accompanied by a reduction of the synaptic vesicles count. Other synapses increased the vesicles quantity with mitochondria collapsing and disappearing. Rare synaptic contacts had patterns similar to Waller degeneration. "Membrane structures" frequently occurred next to axon terminals. Some of postsynaptic dendrites were altered: their swelling and lack of microtubules were evident. The changes observed in the synapses of anterior limbic cortex in schizophrenic patients are believed unspecific.
为了对棘突和树突突触进行电子显微镜特征描述，对尸检的前边缘皮质（24区）进行了研究。在前边缘皮质的I-II层检测到突触的主要变化。随着活性区长度增加，轴突终末的异质性增加。在一部分突触中，终末肿胀伴随着突触小泡数量减少。其他突触则是线粒体塌陷和消失，同时小泡数量增加。罕见的突触接触具有类似于华勒变性的模式。“膜结构”经常出现在轴突终末旁边。一些突触后树突发生改变：明显肿胀且缺乏微管。精神分裂症患者前边缘皮质突触中观察到的变化被认为是非特异性的。
