血浆氢离子浓度对胰腺碳酸氢根分泌的影响。

Effect of plasma H+-ion concentration on pancreatic HCO-3 secretion.

作者信息

Raeder M, Mo A, Aune S

出版信息

Acta Physiol Scand. 1979 Apr;105(4):420-7. doi: 10.1111/j.1748-1716.1979.tb00106.x.

DOI:10.1111/j.1748-1716.1979.tb00106.x

Abstract

The relationship between the rate of pancreatic HCO-3 secretion and plasma H+-ion concentration was investigated in 15 pentothal anesthetized, secretin infused pigs (1.8 C.U./kg b.w. h-1, intravenously) during acute metabolic and respiratory acid-base disturbances. Pancreatic HCO-3 secretion increasd to 196 +/- 10% of control during alkalosis and fell to 41 +/- 4% of control during acidosis. Partial metabolic compensation of respiratory acidosis restored HCO-3 secretion to 87 +/- 6% of control. A proportional relationship was found between HCO-3 secretion and plasma pH. Different, proportional relationships were found between HCO-3 secretion and plasma HCO-3 concentration during metabolic and respiratory acid-base changes. HCO-3 secretion was independent of H+-ion concentration in pancreatic juice. Plasma H+-ion concentration, therefore, seems to determine the rate of pancreatic HCO-3 secretion. This finding supports the hypothesis that a proton pump is responsible for pancreatic HCO-3 secretion.

摘要

在15头经硫喷妥钠麻醉、静脉输注促胰液素（1.8 C.U./kg体重·小时）的猪身上，研究了急性代谢性和呼吸性酸碱紊乱期间胰腺HCO₃⁻分泌速率与血浆H⁺离子浓度之间的关系。碱中毒时胰腺HCO₃⁻分泌增加至对照值的196±10%，酸中毒时降至对照值的41±4%。呼吸性酸中毒的部分代谢性代偿使HCO₃⁻分泌恢复至对照值的87±6%。发现HCO₃⁻分泌与血浆pH之间存在比例关系。在代谢性和呼吸性酸碱变化期间，HCO₃⁻分泌与血浆HCO₃⁻浓度之间发现了不同的比例关系。HCO₃⁻分泌与胰液中的H⁺离子浓度无关。因此，血浆H⁺离子浓度似乎决定了胰腺HCO₃⁻分泌速率。这一发现支持了质子泵负责胰腺HCO₃⁻分泌的假说。