Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Chem Soc Rev. 2023 Feb 20;52(4):1456-1490. doi: 10.1039/d2cs01021f.
Aggregation-induced emission (AIE)-active micelles are a type of fluorescent functional materials that exhibit enhanced emissions in the aggregated surfactant state. They have received significant interest due to their excellent fluorescence efficiency in the aggregated state, remarkable processability, and solubility. AIE-active micelles can be designed through the self-assembly of amphipathic AIE luminogens (AIEgens) and the encapsulation of non-emissive amphipathic molecules in AIEgens. Currently, a wide range of AIE-active micelles have been constructed, with a significant increase in research interest in this area. A series of advanced techniques has been used to characterize AIE-active micelles, such as cryogenic-electron microscopy (Cryo-EM) and confocal laser scanning microscopy (CLSM). This review provides an overview of the synthesis, characterization, and applications of AIE-active micelles, especially their applications in cell and imaging, biological and organic compound sensors, anticancer drugs, gene delivery, chemotherapy, photodynamic therapy, and photocatalytic reactions, with a focus on the most recent developments. Based on the synergistic effect of micelles and AIE, it is anticipated that this review will guide the development of innovative and fascinating AIE-active micelle materials with exciting architectures and functions in the future.
聚集诱导发光（AIE）活性胶束是一种荧光功能材料，在聚集的表面活性剂状态下表现出增强的发光。由于其在聚集状态下的优异荧光效率、显著的加工性能和良好的溶解性，它们受到了广泛关注。AIE 活性胶束可以通过两亲性 AIE 发光体（AIEgens）的自组装和非发光性两亲性分子在 AIEgens 中的包封来设计。目前，已经构建了多种 AIE 活性胶束，该领域的研究兴趣显著增加。一系列先进的技术已被用于表征 AIE 活性胶束，如低温电子显微镜（Cryo-EM）和共聚焦激光扫描显微镜（CLSM）。本综述概述了 AIE 活性胶束的合成、表征和应用，特别是它们在细胞成像、生物和有机化合物传感器、抗癌药物、基因传递、化学疗法、光动力疗法和光催化反应中的应用，重点介绍了最新的发展。基于胶束和 AIE 的协同效应，预计本综述将指导未来具有创新和迷人结构和功能的新型 AIE 活性胶束材料的开发。
