West Bengal Medical Services Corporation Ltd., GN 29, Sector V, Salt Lake City, Kolkata 700091, West Bengal, India.
J Environ Pathol Toxicol Oncol. 2023;42(1):51-64. doi: 10.1615/JEnvironPatholToxicolOncol.2022043545.
Fluoride toxicity, principally by polluted groundwater, is regarded as a momentous global public health risk, as there is no particular and proven treatment for chronic fluoride toxicity i.e., fluorosis which leads to several serious health complications. Scientific literature reveals several medicinal plants and natural products alleviate experimentally induced fluoride toxicity. The present review attempts to collate those experimental studies on medicinal plants and plant derived natural products with fluoride toxicity ameliorative effects. Literature scrutiny was performed by using online bibliographic databases and the studies for the last 15 years were considered. Minerals and semi-synthetic or synthetic analogs of natural products were excluded. Literature study revealed that 25 medicinal plants and 17 natural products exhibited significant protection from fluoride toxicity in experimental animal models i.e., preclinical studies. Two clinical studies on medicinal plants were also found in literature showing beneficial yet poorly correlated outcome. Relevant research in this field could lead to development of a potentially useful agent in therapeutic management of fluoride toxicity in humans.
氟化物毒性，主要来自受污染的地下水，被认为是一个重大的全球公共卫生风险，因为目前尚无针对慢性氟化物毒性（即氟中毒）的特殊且经过验证的治疗方法，而氟中毒会导致多种严重的健康并发症。科学文献表明，一些药用植物和天然产物可缓解实验诱导的氟化物毒性。本综述试图整理具有减轻氟化物毒性作用的药用植物和植物来源天然产物的这些实验研究。通过使用在线书目数据库进行文献研究，并考虑了过去 15 年的研究。排除了矿物质和半合成或合成的天然产物类似物。文献研究表明，25 种药用植物和 17 种天然产物在实验动物模型中（即临床前研究）显示出对氟化物毒性的显著保护作用。文献中还发现了两项关于药用植物的临床研究，显示出有益但相关性差的结果。该领域的相关研究可能会开发出一种在治疗人类氟化物毒性方面具有潜在用途的药物。
