SARS-CoV-2 Nsp1 通过有序和无序结合来抑制宿主翻译。
Order and disorder bound together in SARS-CoV-2 Nsp1 suppress host translation.
机构信息
Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; The Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; The Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
出版信息
Structure. 2023 Feb 2;31(2):121-122. doi: 10.1016/j.str.2023.01.004.
In this issue of Structure, Wang et al. investigate the interplay between folded and disordered regions of the SARS-CoV-2 non-structural protein 1 (Nsp1) that promotes the suppression of host protein translation. Their investigation will lead to novel avenues to therapeutically target critical viral functions necessary for host immune-response suppression.
在本期《结构》杂志中，Wang 等人研究了促进宿主蛋白翻译抑制的 SARS-CoV-2 非结构蛋白 1（Nsp1）的折叠区和无规卷曲区之间的相互作用。他们的研究将为靶向宿主免疫反应抑制所必需的关键病毒功能提供新的治疗方法。
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