Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Cell. 2023 Feb 2;186(3):466-468. doi: 10.1016/j.cell.2022.12.048.
Microbiota-induced IL-17 production mediates CNS processes and animal behavior. However, its role on the peripheral nervous system (PNS) remains largely unknown. Enamorado et al. demonstrate that commensal-specific Th17 cells are recalled following tissue injury to support local nerve regeneration, a process orchestrated by IL-17 signaling on peripheral neurons.
微生物群诱导的 IL-17 产生介导中枢神经系统过程和动物行为。然而，其在外周神经系统 (PNS) 中的作用在很大程度上尚不清楚。Enamorado 等人证明，组织损伤后会召回共生特异性 Th17 细胞以支持局部神经再生，这一过程由外周神经元上的 IL-17 信号协调。
