白细胞介素-17介导的对机会性真菌病原体白色念珠菌的免疫
IL-17-Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans.
作者信息
Conti Heather R, Gaffen Sarah L
机构信息
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261
出版信息
J Immunol. 2015 Aug 1;195(3):780-8. doi: 10.4049/jimmunol.1500909.
IL-17 (IL-17A) has emerged as a key mediator of protection against extracellular microbes, but this cytokine also drives pathology in various autoimmune diseases. Overwhelming data in both humans and mice reveal a clear and surprisingly specific role for IL-17 in protection against the fungus Candida albicans, a commensal microbe of the human oral cavity, gastrointestinal tract, and reproductive mucosa. The IL-17 pathway regulates antifungal immunity through upregulation of proinflammatory cytokines, including IL-6, neutrophil-recruiting chemokines (e.g., CXCL1 and CXCL5), and antimicrobial peptides (e.g., defensins), which act in concert to limit fungal overgrowth. This review focuses on diseases caused by C. albicans, the role of IL-17-mediated immunity in candidiasis, and the implications for clinical therapies for both autoimmune conditions and fungal infections.
白细胞介素-17（IL-17A）已成为抵御细胞外微生物的关键介质，但这种细胞因子也会在多种自身免疫性疾病中引发病变。人和小鼠的大量数据都显示，IL-17在抵御白色念珠菌（一种人类口腔、胃肠道和生殖黏膜的共生微生物）方面发挥着明确且惊人的特定作用。IL-17通路通过上调促炎细胞因子（包括IL-6、招募中性粒细胞的趋化因子（如CXCL1和CXCL5））和抗菌肽（如防御素）来调节抗真菌免疫，这些物质协同作用以限制真菌过度生长。本综述重点关注由白色念珠菌引起的疾病、IL-17介导的免疫在念珠菌病中的作用，以及对自身免疫性疾病和真菌感染临床治疗的意义。
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