Yeragani V K, Rainey J M, Balon R, Berchou R, Lycaki H, Pohl R
Department of Psychiatry, Wayne State University, School of Medicine, Detroit, Michigan.
Acta Psychiatr Scand. 1987 Sep;76(3):324-7. doi: 10.1111/j.1600-0447.1987.tb02902.x.
Eight panic disorder patients participated in a double-blind placebo-controlled infusion study designed to induce panic-anxiety in the laboratory both before and after treatment with tricyclic antidepressants. Pre-infusion heart rates for the first infusion were significantly higher than baseline both before and after treatment. The delta increase in pre-infusion heart rates from baseline and the ratios of pre-infusion heart rates to baseline values were not significantly different between before and after treatment conditions indicating similar levels of arousal during the two pre-infusion periods, while the pre-infusion anxiety ratings after treatment were significantly lower.
八名惊恐障碍患者参与了一项双盲安慰剂对照输注研究，该研究旨在在用三环类抗抑郁药治疗前后在实验室诱发惊恐焦虑。第一次输注前的心率在治疗前后均显著高于基线。治疗前后，输注前心率相对于基线的增量以及输注前心率与基线值的比率没有显著差异，这表明在两个输注前期的唤醒水平相似，而治疗后的输注前焦虑评分显著更低。
