钯催化羰基化反应通用合成苯并吡喃酮使用 CO。

Palladium-Catalyzed Carbonylation for General Synthesis of Aurones Using CO.

机构信息

Hunan Province Key Laboratory of Environmental Catalysis and Waste Recycling, College of Materials and Chemical Engineering, Hunan Institute of Engineering, 411104, Xiangtan, P. R. China.

State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou, 730000, P. R. China.

出版信息

ChemSusChem. 2023 May 19;16(10):e202202365. doi: 10.1002/cssc.202202365. Epub 2023 Mar 23.

DOI:10.1002/cssc.202202365

PMID:36737418

Abstract

The carbonylation of alkynes using CO to generate aurones is to date unknown. In this study, a palladium-catalyzed carbonylation of terminal aromatic alkynes and the waste hydrosilane, poly(methylhydrosiloxane) (PMHS), is carried out with 2-iodophenol using CO to produce aurones. A variety of terminal alkynes and substituted 2-iodophenols are transformed into aurones in good yields. Preliminary mechanistic studies indicate that silyl formate, generated from CO and PMHS, plays a crucial role in the carbonylation reaction.

摘要

迄今为止，人们还不知道如何利用 CO 将炔烃羰基化为奥酮。在这项研究中，使用 CO 将末端芳基炔烃和废硅氢烷聚甲基氢硅氧烷（PMHS）与 2-碘苯酚进行钯催化羰基化反应，生成奥酮。各种末端炔烃和取代的 2-碘苯酚都以良好的收率转化为奥酮。初步的机理研究表明，CO 和 PMHS 生成的甲硅基甲酸酯在羰基化反应中起着关键作用。