Lehrstuhl Anorganische Chemie II-Katalysatordesign, Sustainable Chemistry Centre, Universität Bayreuth, 95440, Bayreuth, Germany.
Nat Commun. 2023 Feb 3;14(1):595. doi: 10.1038/s41467-023-36220-w.
The discovery of reactions is a central topic in chemistry and especially interesting if access to compound classes, which have not yet been synthesized, is permitted. N-Heterocyclic compounds are very important due to their numerous applications in life and material science. We introduce here a consecutive three-component reaction, classes of N-heterocyclic compounds, and the associated synthesis concept (regenerative cyclisation). Our reaction starts with a diamine, which reacts with an amino alcohol via dehydrogenation, condensation, and cyclisation to form a new pair of amines that undergoes ring closure with an aldehyde, carbonyldiimidazole, or a dehydrogenated amino alcohol. Hydrogen is liberated in the first reaction step and the dehydrogenation catalyst used is based on manganese.
反应的发现是化学的一个核心主题，如果能够获得尚未合成的化合物类别，那么这将非常有趣。由于 N-杂环化合物在生命科学和材料科学中有许多应用，因此它们非常重要。我们在这里介绍了一个连续的三组分反应、N-杂环化合物的类别以及相关的合成概念（再生环化）。我们的反应从二胺开始，二胺通过脱氢、缩合和环化与氨基醇反应，形成一对新的胺，然后与醛、羰基二咪唑或脱氢氨基醇进行环合。在第一步反应中释放出氢气，所用的脱氢催化剂基于锰。
