Baeckert P, Bucher H U, Fallenstein F, Fanconi S, Huch R, Duc G
Division of Neonatology, University of Zürich, Switzerland.
Adv Exp Med Biol. 1987;220:165-9. doi: 10.1007/978-1-4613-1927-6_29.
We tested the hypothesis that hyperoxemia defined as arterial PO2 above 12 kPa can be detected by pulse oximetry using 95% oxygen saturation as the upper limit. Thirty artificially ventilated neonates with an indwelling arterial catheter were studied registrating transcutaneous oxygen saturation (Ohmeda Biox 3700 Pulse Oximeter) and transcutaneous PO2 continuously during a 4-hour period and measuring arterial oxygen saturation and PO2 intermittently. 46 episodes of arterial hyperoxemia were observed. Pulse oximetry had a sensitivity of 30%, detecting 14 of these 46 hyperoxemic episodes, and a specificity of 93%. The accuracy for separating hyperoxemia from normoxemia by pulse oximetry could be improved by shifting the cut-off point from 95% to 92%. With this optimal cut-off point sensitivity was 70% and specificity 62%. We conclude that pulse oximetry is not reliable for detection of hyperoxemia.
使用95%的氧饱和度作为上限，通过脉搏血氧饱和度测定法能够检测出定义为动脉血氧分压高于12 kPa的高氧血症。对30例留置动脉导管的人工通气新生儿进行了研究，在4小时内持续记录经皮血氧饱和度（Ohmeda Biox 3700脉搏血氧饱和度测定仪）和经皮血氧分压，并间歇性测量动脉血氧饱和度和血氧分压。观察到46次动脉高氧血症发作。脉搏血氧饱和度测定法的灵敏度为30%，检测出这46次高氧血症发作中的14次，特异性为93%。将临界值从95%调整到92%，可提高脉搏血氧饱和度测定法区分高氧血症和正常氧血症的准确性。在此最佳临界值下，灵敏度为70%，特异性为62%。我们得出结论，脉搏血氧饱和度测定法检测高氧血症并不可靠。
