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记忆管弦乐队:星形胶质细胞的贡献。

The Memory Orchestra: Contribution of Astrocytes.

机构信息

State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.

出版信息

Neurosci Bull. 2023 Mar;39(3):409-424. doi: 10.1007/s12264-023-01024-x. Epub 2023 Feb 4.

Abstract

For decades, memory research has centered on the role of neurons, which do not function in isolation. However, astrocytes play important roles in regulating neuronal recruitment and function at the local and network levels, forming the basis for information processing as well as memory formation and storage. In this review, we discuss the role of astrocytes in memory functions and their cellular underpinnings at multiple time points. We summarize important breakthroughs and controversies in the field as well as potential avenues to further illuminate the role of astrocytes in memory processes.

摘要

几十年来,记忆研究一直集中在神经元的作用上,神经元不是孤立运作的。然而,星形胶质细胞在调节神经元的募集和局部及网络水平的功能方面发挥着重要作用,为信息处理以及记忆的形成和储存奠定了基础。在这篇综述中,我们讨论了星形胶质细胞在记忆功能中的作用及其在多个时间点的细胞基础。我们总结了该领域的重要突破和争议,以及进一步阐明星形胶质细胞在记忆过程中作用的潜在途径。

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