Diafas A, Dastiridou A, Samouilidou M, Tzamalis A, Mataftsi A, Tsinopoulos I, Kozobolis V, Ziakas N
2(nd) Departamento de Oftalmología, Universidad Aristóteles de Tesalónica, Facultad de Medicina, Hospital General Papageorgiou, Tesalónica, Greece; St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom.
2(nd) Departamento de Oftalmología, Universidad Aristóteles de Tesalónica, Facultad de Medicina, Hospital General Papageorgiou, Tesalónica, Greece.
Arch Soc Esp Oftalmol (Engl Ed). 2023 Mar;98(3):125-131. doi: 10.1016/j.oftale.2023.02.003. Epub 2023 Feb 2.
To investigate the effect of acetazolamide (AZ) on the retinal and choroidal ocular microvasculature in the macula and radial peripapillary capillaries (RPC) of the optic disc with OCT Angiography (OCTA).
Nine-month observational cross-sectional study. Forty-five eyes from 45 healthy participants who underwent cataract surgery were recruited. Macular retina and choriocapillaris vessel density (VD) and RPC VD in the optic disc area were compared before and 60min after 250mg acetazolamide per os. Intraocular pressure (IOP) and systemic blood pressure (BP) were also measured before each scan.
Mean age was 73.1±6.9 years. VDs in the superficial (SCP) and deep (DCP) capillary plexus of the retina and the choriocapillaris (CC) in the macular area showed no significant change (P>.5, for all parameters). VD in the RPC showed no significant change with AZ (P>.5, for all parameters). Foveal and parafoveal thickness increased from 248.98 (±23.89) to 250.33 (±23.74) and from 311.62 (±16.53) to 311.98 (±16.38) (P<.001 and P=.046), respectively. IOP decreased from 13.2 (±3.0) mmHg to 11.8 (±3.2) mmHg (P<.001), while systolic and diastolic BP decreased from 144.8 (±21.8) to 137.7 (±19.0) and from 80.0 (±12.7) to 76.2 (±11.7) (P=.021 and P=.030), respectively.
OCTA imaging did not reveal any significant changes in the VD of the optic disc or the retinal and choroidal VD in the macula with oral AZ one hour after its administration in otherwise healthy participants who underwent cataract surgery.
采用光学相干断层扫描血管造影（OCTA）研究乙酰唑胺（AZ）对黄斑区视网膜和脉络膜眼部微血管以及视盘放射状视乳头周围毛细血管（RPC）的影响。
为期9个月的观察性横断面研究。招募了45名接受白内障手术的健康参与者的45只眼睛。比较口服250mg乙酰唑胺前和服药后60分钟黄斑区视网膜和脉络膜毛细血管层血管密度（VD）以及视盘区域RPC的VD。每次扫描前还测量眼压（IOP）和全身血压（BP）。
平均年龄为73.1±6.9岁。视网膜浅层（SCP）和深层（DCP）毛细血管丛以及黄斑区脉络膜毛细血管（CC）的VD无显著变化（所有参数P>.5）。RPC的VD随AZ无显著变化（所有参数P>.5）。中央凹和旁中央凹厚度分别从248.98（±23.89）增加到250.33（±23.74）以及从311.62（±16.53）增加到311.98（±16.38）（分别为P<.001和P=.046）。IOP从13.2（±3.0）mmHg降至11.8（±3.2）mmHg（P<.001），而收缩压和舒张压分别从144.8（±21.8）降至137.7（±19.0）以及从80.0（±12.7）降至76.2（±11.7）（分别为P=.021和P=.030）。
在接受白内障手术的健康参与者中，口服AZ一小时后，OCTA成像未显示视盘VD或黄斑区视网膜和脉络膜VD有任何显著变化。
