Li Sujuan, Lu Xiaozi, Qiu Yan, Teng Ziwei, Zhao Ziru, Xu Xuelei, Tang Hui, Xiang Hui, Chen Jindong, Wang Bolun, Wu Haishan
National Clinical Research Center for Mental Disorders, , Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Qingdao Memtal Health Center, Qingdao, China.
J Affect Disord. 2023 Apr 14;327:159-166. doi: 10.1016/j.jad.2023.01.105. Epub 2023 Feb 2.
Cognitive impairment is one of the major symptoms of individuals with bipolar disorder (BD). Purine system disorders may play an important role in cognitive dysfunction. So far, the relationship between cognitive deficits and purinergic metabolism in BD has been seldom discussed in previous studies. This study aims to explore its relevance and potential biological mechanisms.
In this cross-sectional study, 205 first time diagnosed drug-naive individuals with BD and 97 healthy volunteers were recruited. The uric acid(UA) level was measured using automatic biochemical analyzer, and cognitive function was assessed by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Stroop color-word test. In addition, general information and clinical symptoms were collected and evaluated.
In this study, the UA level of BD group (U = 8475.000, p = 0.038) was found to be significantly higher than that of the healthy controls, but the scores of RBANS (t = -11.302, p < 0.001) and Stroop color-word test (t = -6.962, p < 0.001) were significantly lower than that of the healthy controls. In gender subgroup analysis, females had lower UA level and higher RBANS scores. In correlation analysis, the cognitive function of individuals with BD was found to present a significant negative correlation with UA level in attention (r = -0.23, p = 0.001) and delayed memory(r = -0.16, p = 0.022).
This is a cross-sectional design.
Elevated UA levels may be a potential mechanism of cognitive impairment in BD. This provides a new possible strategy for the prevention and treatment of cognitive impairment in BD.
认知障碍是双相情感障碍（BD）患者的主要症状之一。嘌呤系统紊乱可能在认知功能障碍中起重要作用。到目前为止，BD患者认知缺陷与嘌呤能代谢之间的关系在以往研究中很少被讨论。本研究旨在探讨其相关性及潜在的生物学机制。
在这项横断面研究中，招募了205例首次诊断为未用药的BD患者和97名健康志愿者。使用自动生化分析仪测量尿酸（UA）水平，通过可重复神经心理状态评估量表（RBANS）和Stroop色词测验评估认知功能。此外，收集并评估一般信息和临床症状。
在本研究中，发现BD组的UA水平（U = 8475.000，p = 0.038）显著高于健康对照组，但RBANS评分（t = -11.302，p < 0.001）和Stroop色词测验评分（t = -6.962，p < 0.001）显著低于健康对照组。在性别亚组分析中，女性的UA水平较低，RBANS评分较高。在相关性分析中，发现BD患者的认知功能在注意力方面与UA水平呈显著负相关（r = -0.23，p = 0.001），在延迟记忆方面也呈显著负相关（r = -0.16，p = 0.022）。
这是一项横断面设计。
UA水平升高可能是BD患者认知障碍的潜在机制。这为BD患者认知障碍的预防和治疗提供了一种新的可能策略。
