血清脑源性神经营养因子水平低与双相障碍 II 型和 MDD 中当前抑郁发作的未经药物治疗的患者的认知障碍有关。

Low BDNF levels in serum are associated with cognitive impairments in medication-naïve patients with current depressive episode in BD II and MDD.

机构信息

National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.

Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.

出版信息

J Affect Disord. 2021 Oct 1;293:90-96. doi: 10.1016/j.jad.2021.06.018. Epub 2021 Jun 18.

DOI:10.1016/j.jad.2021.06.018

PMID:34175594

Abstract

OBJECTIVE

This study aimed to investigate the role of Brain-derived neurotrophic factor (BDNF) in clinical and cognitive outcomes in medication-naïve patients with Bipolar type II disorder (BD II) and Major depressive disorder (MDD).

METHODS

45 outpatients with BD II, 40 outpatients with MDD and 40 healthy controls (HCs) were recruited, and sociodemographic and clinical data were collected. Their BDNF serum levels were measured and analyzed with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).

RESULTS

BDNF levels were significantly lower in BD II patients than in MDD patients and HCs (p = 0.001). BD II and MDD patients had similar cognitive performance deficits shown on Attention (p = 0.001), Delayed memory (p = 0.001), and RBANS total score (p = 0.001). BDNF levels were positively associated with Visuospatial / constructional and Stroop color-word in BD II group, and with language in MDD group. The area under the curve (AUC) of the ROC analysis in BD II vs. MDD was 0.664, therefore, BDNF levels could not distinguish BD II from MDD.

CONCLUSION

Our study showed the decreased serum BDNF in MDD and BD II patients, suggesting BDNF may be involved in the pathophysiology of MDD and BD II. BDNF and cognitive deficits are both of low efficiency in distinguishing BD II from MDD. Decrease of BDNF may potentially indicate cognitive dysfunction in BD II and MDD patients with a current depressive episode.

摘要

目的

本研究旨在探讨脑源性神经营养因子（BDNF）在未经药物治疗的双相情感障碍 II 型（BD II）和重度抑郁症（MDD）患者的临床和认知结局中的作用。

方法

招募了 45 名 BD II 门诊患者、40 名 MDD 门诊患者和 40 名健康对照者（HCs），收集了社会人口学和临床数据。测量了他们的 BDNF 血清水平，并使用重复神经心理状态评估量表（RBANS）进行了分析。

结果

BD II 患者的 BDNF 水平明显低于 MDD 患者和 HCs（p=0.001）。BD II 和 MDD 患者的注意力（p=0.001）、延迟记忆（p=0.001）和 RBANS 总分（p=0.001）的认知表现缺陷相似。BD II 组中，BDNF 水平与视空间/结构和 Stroop 颜色-词呈正相关，而 MDD 组中与语言呈正相关。BD II 与 MDD 的 ROC 分析的曲线下面积（AUC）为 0.664，因此，BDNF 水平不能区分 BD II 与 MDD。

结论

我们的研究表明，MDD 和 BD II 患者的血清 BDNF 水平降低，提示 BDNF 可能参与 MDD 和 BD II 的病理生理学过程。BDNF 和认知缺陷在区分 BD II 与 MDD 方面效率均较低。BDNF 的减少可能潜在地表明当前抑郁发作的 BD II 和 MDD 患者存在认知功能障碍。