帕金森病炎症生物标志物的系统评价与荟萃分析。

A systematic review and meta-analysis of inflammatory biomarkers in Parkinson's disease.

作者信息

Qu Yi, Li Jiangting, Qin Qixiong, Wang Danlei, Zhao Jingwei, An Ke, Mao Zhijuan, Min Zhe, Xiong Yongjie, Li Jingyi, Xue Zheng

机构信息

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

NPJ Parkinsons Dis. 2023 Feb 4;9(1):18. doi: 10.1038/s41531-023-00449-5.

Neuroinflammation plays a crucial role in the pathogenesis of Parkinson's disease (PD), but controversies persist. Studies reporting concentrations of blood or cerebrospinal fluid (CSF) markers for patients with PD and controls were included and extracted. Pooled Hedges'g was adopted to illustrate comparisons, and covariates were used to explore sources of heterogeneity. Finally, 152 studies were included. Increased IL-6, TNF-α, IL-1β, STNFR1, CRP, CCL2, CX3CL1, and CXCL12 levels and decreased INF-γ and IL-4 levels were noted in the PD group. In addition, increased CSF levels of IL-6, TNF-α, IL-1β, CRP and CCL2 were revealed in patients with PD compared to controls. Consequently, significantly altered levels of inflammatory markers were verified between PD group and control, suggesting that PD is accompanied by inflammatory responses in both the peripheral blood and CSF. This study was registered with PROSPERO, CRD42022349182.

神经炎症在帕金森病（PD）的发病机制中起着关键作用，但争议仍然存在。纳入并提取了报告帕金森病患者和对照组血液或脑脊液（CSF）标志物浓度的研究。采用合并的Hedges'g来进行比较，并使用协变量来探索异质性来源。最终纳入了152项研究。在帕金森病组中，观察到白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、可溶性肿瘤坏死因子受体1（STNFR1）、C反应蛋白（CRP）、趋化因子配体2（CCL2）、趋化因子CX3CL1和CXCL12水平升高，而干扰素-γ（INF-γ）和白细胞介素-4（IL-4）水平降低。此外，与对照组相比，帕金森病患者脑脊液中IL-6、TNF-α、IL-1β、CRP和CCL2水平升高。因此，在帕金森病组和对照组之间证实了炎症标志物水平的显著改变，表明帕金森病在外周血和脑脊液中均伴有炎症反应。本研究已在国际前瞻性系统评价注册库（PROSPERO）注册，注册号为CRD42022349182。