Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Oncogene. 2023 Mar;42(10):711-724. doi: 10.1038/s41388-023-02593-x. Epub 2023 Feb 4.
Cancer cells rely on certain extracellular nutrients to sustain their metabolism and growth. Solute carrier (SLC) transporters enable cells to acquire extracellular nutrients or shuttle intracellular nutrients across organelles. However, the function of many SLC transporters in cancer is unknown. Determining the key SLC transporters promoting cancer growth could reveal important therapeutic opportunities. Here we summarize recent findings and knowledge gaps on SLC transporters in cancer. We highlight existing inhibitors for studying these transporters, clinical trials on treating cancer by blocking transporters, and compensatory transporters used by cancer cells to evade treatment. We propose targeting transporters simultaneously or in combination with targeted therapy or immunotherapy as alternative strategies for effective cancer therapy.
癌细胞依赖某些细胞外营养物质来维持其新陈代谢和生长。溶质载体 (SLC) 转运蛋白使细胞能够获取细胞外营养物质或在细胞器之间转运细胞内营养物质。然而，许多 SLC 转运蛋白在癌症中的功能尚不清楚。确定促进癌症生长的关键 SLC 转运蛋白可能会揭示重要的治疗机会。在这里，我们总结了 SLC 转运蛋白在癌症中的最新发现和知识空白。我们强调了用于研究这些转运蛋白的现有抑制剂、通过阻断转运蛋白治疗癌症的临床试验，以及癌细胞用来逃避治疗的代偿性转运蛋白。我们建议同时或与靶向治疗或免疫治疗联合靶向转运蛋白作为有效癌症治疗的替代策略。
