Department of Ophthalmology, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Department of Endocrinology, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Biomed Eng Online. 2023 Feb 4;22(1):7. doi: 10.1186/s12938-023-01073-3.
Thyroid-associated ophthalmopathy (TAO) is an autoimmune disorder. It has discriminable appearance. This study was conducted to dig the clinical significance of demographic characteristics and ophthalmologic diagram features in TAO diagnosis and stage/severity evaluation.
We included 320 males and 633 females, with an average age of 41.75 ± 13.75. A majority of TAO patients had hyperthyroidism, and most of them were in the inactive stage and at the moderate level. The thyroid function type, stage and severity were closely associated with hypopsia, eyelid congestion, conjunctival congestion, corneal ulcer, ocular motility disorder, best corrected visual acuity, and extraocular muscle thickening. Using these features, we established different logistic regression models to predict thyroid function subtypes, abnormal thyroid function, stage, and severity, in which the AUC of the ROC curve and accuracies were satisfactory.
Together, TAO subtype, stage and severity can be diagnosed by auxiliary references including demographic factors, symptoms from complains, and image features. These non-invasive indices can be applied in a timely manner in clinical estimating TAO status.
甲状腺相关眼病（TAO）是一种自身免疫性疾病，具有明显的特征。本研究旨在挖掘人口统计学特征和眼科图特征在 TAO 诊断和分期/严重程度评估中的临床意义。
共纳入 320 例男性和 633 例女性，平均年龄为 41.75±13.75 岁。大多数 TAO 患者患有甲状腺功能亢进症，大多数处于活动期和中度水平。甲状腺功能类型、分期和严重程度与视力下降、眼睑充血、结膜充血、角膜溃疡、眼球运动障碍、最佳矫正视力和眼外肌增厚密切相关。利用这些特征，我们建立了不同的逻辑回归模型来预测甲状腺功能亚型、异常甲状腺功能、分期和严重程度，ROC 曲线的 AUC 和准确率令人满意。
综上所述，TAO 亚型、分期和严重程度可以通过辅助参考指标包括人口统计学因素、症状和图像特征来诊断。这些非侵入性指标可及时应用于临床评估 TAO 状态。
