基于癌症功能状态的胃癌分子亚型。
Cancer functional states-based molecular subtypes of gastric cancer.
机构信息
Department of General Surgery, The Second Affiliated Hospital of Nanchang University, No.1 Minde Road, Donghu District, Nanchang, 330006, Jiangxi, China.
Jiangxi Province Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
出版信息
J Transl Med. 2023 Feb 4;21(1):80. doi: 10.1186/s12967-023-03921-1.
BACKGROUND
The treatment of gastric cancer remains a challenge.
METHODS
We divided gastric cancer into three subtypes based on 14 cancer functional states. We investigated differences between subtypes through multi-omics data, especially at the single-cell level, which allowed us to analyze differences from the perspective of each type of cell rather than the whole.
RESULTS
The cluster 1 is characterized by high levels of tumor progression-related cancer functional status, worst survival outcomes, low metabolic level, high infiltration of immunosuppressive cells, high copy number variations (CNV), and low tumor mutational burden (TMB). The cluster 2 is characterized by low levels of tumor progression-related cancer functional status, favorable prognosis, moderate metabolic level, low immune cell infiltration, high CNV, and moderate TMB. Then, the cluster 3 is characterized by the high level of all cancer functional status, high metabolic level, low CNV, high TMB, high infiltration of immune cells with high cytotoxicity, and better response to immunotherapy. We also established a prognostic model based on cancer functional status and validated its robustness.
CONCLUSIONS
Collectively, our study identified gastric cancer subtypes and provided new insights into the clinical treatment of gastric cancer.
背景
胃癌的治疗仍然是一个挑战。
方法
我们根据 14 种癌症功能状态将胃癌分为三个亚型。我们通过多组学数据，特别是单细胞水平，研究了亚型之间的差异，这使我们能够从每种细胞类型的角度而不是整体角度分析差异。
结果
簇 1 的特点是高水平的肿瘤进展相关癌症功能状态、最差的生存结果、低代谢水平、高免疫抑制细胞浸润、高拷贝数变异（CNV）和低肿瘤突变负担（TMB）。簇 2 的特点是低水平的肿瘤进展相关癌症功能状态、有利的预后、中等代谢水平、低免疫细胞浸润、高 CNV 和中等 TMB。然后，簇 3 的特点是所有癌症功能状态水平高、代谢水平高、CNV 低、TMB 高、高细胞毒性免疫细胞浸润和对免疫治疗的更好反应。我们还基于癌症功能状态建立了一个预后模型，并验证了其稳健性。
结论
总的来说，我们的研究确定了胃癌亚型，并为胃癌的临床治疗提供了新的见解。
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