Clark J H, Russell G J, Fitzgerald J F, Nagamori K E
Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indianapolis.
Am J Dis Child. 1987 Nov;141(11):1210-2. doi: 10.1001/archpedi.1987.04460110080028.
Twenty-five children with chronic constipation underwent serial monitoring of serum beta-carotene, retinol (vitamin A1), and alpha-tocopherol (vitamin E) levels during mineral oil therapy. Mineral oil was administered between meals. Patients were monitored for up to four months of therapy. Mean serum beta-carotene levels fell from 1.0 +/- 0.5 mumol/L (55.7 +/- 26.0 micrograms/dL) to 0.7 +/- 0.4 mumol/L (35.9 +/- 22.1 micrograms/dL) after the first month of mineral oil therapy and remained depressed throughout the remainder of the study. Serum alpha-tocopherol levels remained unchanged throughout the observation period. There was a modest increase in serum retinol levels during the study, especially after three months (from 1.48 +/- 0.84 mumol/L [42.3 +/- 24.1 micrograms/dL] to 2.22 +/- 0.77 mumol/L [63.5 +/- 22.1 micrograms/dL]). We conclude that while a short course of mineral oil can induce a reduction in the serum level of beta-carotene, the treatment has no adverse effect on serum levels of retinol and alpha-tocopherol.
25名患有慢性便秘的儿童在接受矿物油治疗期间接受了血清β-胡萝卜素、视黄醇（维生素A1）和α-生育酚（维生素E）水平的连续监测。矿物油在两餐之间服用。对患者进行了长达四个月的治疗监测。在矿物油治疗的第一个月后，血清β-胡萝卜素平均水平从1.0±0.5μmol/L（55.7±26.0μg/dL）降至0.7±0.4μmol/L（35.9±22.1μg/dL），并在研究的其余时间内一直处于较低水平。血清α-生育酚水平在整个观察期内保持不变。在研究期间，血清视黄醇水平有适度升高，尤其是在三个月后（从1.48±0.84μmol/L[42.3±24.1μg/dL]升至2.22±0.77μmol/L[63.5±22.1μg/dL]）。我们得出结论，虽然短期的矿物油治疗可导致血清β-胡萝卜素水平降低，但该治疗对血清视黄醇和α-生育酚水平没有不良影响。
