Rokkas T, Pursey C, Uzoechina E, Dorrington L, Simmons N A, Filipe M I, Sladen G E
Department of Clinical Bacteriology, UMDS Guy's Hospital, London, United Kingdom.
Am J Gastroenterol. 1987 Nov;82(11):1149-52.
Non-ulcer dyspepsia (NUD) is a poorly understood syndrome often present in association with gastritis. Among patients undergoing gastroscopy, some with NUD have a gastric mucosa colonized by the campylobacter-like organism, Campylobacter pylori. We therefore studied prospectively 55 consecutive patients with NUD and 15 normal controls to determine the prevalence of C. pylori organisms, and to investigate their association with histological gastritis, macroscopic evidence of gastritis, sex, smoking, alcohol consumption, and dyspeptic symptoms. We found a 45.4% prevalence in NUD patients which was statistically significantly higher than the 13.33% prevalence in the control group (p less than 0.05). We also found a close association between C. pylori and microscopic evidence of gastritis (p less than 0.001), male sex (p less than 0.001), and postprandial bloating (p less than 0.05). We did not find any significant association between C. pylori and macroscopic evidence of gastritis, smoking, alcohol consumption and other dyspeptic symptoms. Our findings suggest that C. pylori may play a pathogenic role in NUD.
非溃疡性消化不良（NUD）是一种了解甚少的综合征，常与胃炎相关。在接受胃镜检查的患者中，一些NUD患者的胃黏膜被类似弯曲菌的幽门螺杆菌定植。因此，我们前瞻性地研究了55例连续的NUD患者和15例正常对照，以确定幽门螺杆菌的感染率，并研究其与组织学胃炎、胃炎的宏观表现、性别、吸烟、饮酒及消化不良症状的关系。我们发现NUD患者的感染率为45.4%，在统计学上显著高于对照组的13.33%（p<0.05）。我们还发现幽门螺杆菌与胃炎的微观表现（p<0.001）、男性（p<0.001）及餐后腹胀（p<0.05）密切相关。我们未发现幽门螺杆菌与胃炎的宏观表现、吸烟、饮酒及其他消化不良症状之间存在任何显著关联。我们的研究结果表明，幽门螺杆菌可能在NUD中起致病作用。
