Sarnelli Giovanni, Cuomo Rosario, Janssens Jozef, Tack Jan
Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.
Dig Dis Sci. 2003 Dec;48(12):2229-36. doi: 10.1023/b:ddas.0000007856.71462.6c.
Helicobacter pylori (HP) has been proposed as a mechanism of functional dyspepsia, but its role is still unclear. Our aim was to investigate the association between HP infection and dyspeptic symptoms and to verify whether the infection affects the pathophysiological mechanism of functional dyspepsia. The presence of HP and its association with dyspeptic symptoms were studied in 326 patients. Also, the effect of HP infection on solid/liquid gastric emptying rates, gastric sensitivity, and accommodation to meal was studied. HP was present in 17% of the patients, who showed symptom prevalence similar to that of HP-negative patients. Presence of HP did not significantly affect gastric emptying rates for solids and liquids, discomfort sensitivity thresholds (8.7 +/- 0.3 vs 9.8 +/- 0.9 mm Hg), or meal-induced gastric relaxation (133 +/- 12 vs 125 +/- 29 ml; all P's NS). In conclusion, in patients with functional dyspepsia the presence of HP infection does not seem to affect significantly the overall prevalence of symptoms or the gastric sensory-motor functions.
幽门螺杆菌（HP）被认为是功能性消化不良的一种发病机制，但其作用仍不明确。我们的目的是研究HP感染与消化不良症状之间的关联，并验证该感染是否影响功能性消化不良的病理生理机制。对326例患者进行了HP检测及其与消化不良症状的相关性研究。此外，还研究了HP感染对固体/液体胃排空率、胃敏感性和进餐适应性的影响。17%的患者存在HP感染，其症状发生率与HP阴性患者相似。HP感染并未显著影响固体和液体的胃排空率、不适敏感阈值（8.7±0.3 vs 9.8±0.9 mmHg）或进餐引起的胃舒张（133±12 vs 125±29 ml；所有P值均无统计学意义）。总之，在功能性消化不良患者中，HP感染似乎并未显著影响症状的总体发生率或胃感觉运动功能。
