Zeng S D, Yang L
Department of Burns, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023 Jan 20;39(1):75-80. doi: 10.3760/cma.j.cn501225-20220216-00030.
The diagnosis and treatment of chronic refractory wounds on body surface has always been full of challenges, and it also poses a huge burden on medical care and society. High-throughput sequencing combined with omics analysis can reveal potential mechanisms of chronic wound formation, and identify potential biomarkers related to diagnosis, prognosis, and screening of chronic wound. Combined with multiple levels of omics analysis, the detailed molecular mechanism of chronic wound development can be further explored and understood, so as to provide clues for the formulation of personalized treatment methods and lay a solid foundation for the precision medicine of chronic wounds. Therefore, this review addresses the recent progress of various omics analyses in chronic refractory wounds on body surface.
体表慢性难愈性创面的诊断与治疗一直充满挑战，也给医疗和社会带来了巨大负担。高通量测序结合组学分析能够揭示慢性创面形成的潜在机制，并识别与慢性创面诊断、预后及筛查相关的潜在生物标志物。结合多层次组学分析，可进一步探究和理解慢性创面发展的详细分子机制，从而为制定个性化治疗方法提供线索，为慢性创面的精准医疗奠定坚实基础。因此，本综述阐述了各种组学分析在体表慢性难愈性创面上的最新进展。
