以氯e6为光敏剂的全身光动力疗法治疗结节性基底细胞癌：一例报告
Systemic Photodynamic Therapy With Chlorine e6 as a Photosensitizer for the Treatment of Nodular BCC: A Case Report.
作者信息
Mansuri Parvin, Tabaie Seyed Mehdi, Naderi Mina Sadat, Kebriti Katayoun, Esmaeeli Djavid Gholamreza, Shirkavand Afshan
机构信息
Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran.
Department of Biophysics, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.
出版信息
J Lasers Med Sci. 2022 Oct 11;13:e44. doi: 10.34172/jlms.2022.44. eCollection 2022.
Photodynamic therapy (PDT) is a demonstrated therapeutic method for basal cellcarcinoma (BCC), which is the most common human cancer. Here, we present a case report about systemic PDT with chlorine e6 as a photosensitizer (PS) for BCC treatment. A 78-year-old man was diagnosed with a history of a 4-year nodular BCC in the nasal area. The patient was under control and treatment for hypertension and type 2 diabetes. Chlorine e6 was injected intravenously at a 0.08 mg/kg dosage in 500 cc normal saline within 20 minutes. Three hours after injection, laser irradiation was performed with a wavelength of 665 nm, a dosage of 150 J/cm, and an irradiance value of 150 mW/cm. His nodular BCC was completely cured without any side effects after one session of PDT with chlorine e6. Systemic PDT with chlorine e6 as a PS may be safe and effective in removing BCC lesions due to the data obtained in a two-month follow-up.
光动力疗法（PDT）是一种已被证实的治疗基底细胞癌（BCC）的方法，基底细胞癌是人类最常见的癌症。在此，我们报告一例以氯e6作为光敏剂（PS）进行全身光动力疗法治疗基底细胞癌的病例。一名78岁男性被诊断患有鼻部4年结节性基底细胞癌病史。该患者正在接受高血压和2型糖尿病的控制与治疗。将氯e6以0.08 mg/kg的剂量在20分钟内静脉注射到500 cc生理盐水中。注射后3小时，使用波长665 nm、剂量150 J/cm²和辐照值150 mW/cm²进行激光照射。在使用氯e6进行一次光动力疗法后，他的结节性基底细胞癌完全治愈，且无任何副作用。基于两个月随访获得的数据，以氯e6作为光敏剂的全身光动力疗法在去除基底细胞癌病变方面可能是安全有效的。
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