Bang Yu Min, Song Yoojin, Yun Seo Jung, Seo Han Gil, Chang Won Hyuk
Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
Brain Neurorehabil. 2021 Jul 13;14(2):e13. doi: 10.12786/bn.2021.14.e13. eCollection 2021 Jul.
The objective of this study is to investigate the clinical and demographic factors that influence the quality of life in patients with Parkinson's disease (PD). This is a cross-sectional observational study of 47 patients in 2 hospitals with PD. All participants were asked to complete a disease-specific quality of life (QoL) questionnaire (PDQ-39). We gave a structured questionnaire interview and did a complete neurological examination on the same day. Additionally, we measured depression and dependency with the Geriatric Depression Scale-Short Form (GDS-SF) and the Korean version of the Modified Barthel Index (K-MBI). The PDQ-39 had a significant relationship with each motor part of the Unified Parkinson's Disease Rating Scale, the Korean Mini-Mental State Examination (K-MMSE), the GDS-SF, and the K-MBI (p < 0.05). The factors that independently contributed to the PDQ-39 scores were K-MMSE, GDS-SF, and K-MBI (p < 0.05). Factors having the greatest influence on the PDQ-39 were K-MBI, K-MMSE, and GDS-SF in that order. In addition, the mobility item in the K-MBI was independently a significant relating factor in the PDQ-39 (p < 0.05). These results demonstrated that dependency, especially with the mobility issue, was the greatest influence on the QoL in patients with PD.
本研究的目的是调查影响帕金森病（PD）患者生活质量的临床和人口统计学因素。这是一项对两家医院的47例PD患者进行的横断面观察性研究。所有参与者均被要求完成一份特定疾病的生活质量（QoL）问卷（PDQ - 39）。我们在同一天进行了结构化问卷调查访谈并进行了全面的神经学检查。此外，我们使用老年抑郁量表简表（GDS - SF）和韩国版改良巴氏指数（K - MBI）测量了抑郁和依赖程度。PDQ - 39与统一帕金森病评定量表的每个运动部分、韩国简易精神状态检查表（K - MMSE）、GDS - SF和K - MBI均存在显著相关性（p < 0.05）。对PDQ - 39得分有独立贡献的因素是K - MMSE、GDS - SF和K - MBI（p < 0.05）。对PDQ - 39影响最大的因素依次为K - MBI、K - MMSE和GDS - SF。此外，K - MBI中的活动能力项目在PDQ - 39中是独立的显著相关因素（p < 0.05）。这些结果表明，依赖，尤其是活动能力问题，对PD患者的生活质量影响最大。
