评估非人类灵长类动物的抑郁样和焦虑样行为。
Evaluating depression- and anxiety-like behaviors in non-human primates.
作者信息
Ausderau Karla K, Colman Ricki J, Kabakov Sabrina, Schultz-Darken Nancy, Emborg Marina E
机构信息
Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States.
Waisman Center, University of Wisconsin-Madison, Madison, WI, United States.
出版信息
Front Behav Neurosci. 2023 Jan 19;16:1006065. doi: 10.3389/fnbeh.2022.1006065. eCollection 2022.
Depression and anxiety are some of the most prevalent and debilitating mental health conditions in humans. They can present on their own or as co-morbidities with other disorders. Like humans, non-human primates (NHPs) can develop depression- and anxiety-like signs. Here, we first define human depression and anxiety, examine equivalent species-specific behaviors in NHPs, and consider models and current methods to identify and evaluate these behaviors. We also discuss knowledge gaps, as well as the importance of evaluating the co-occurrence of depression- and anxiety-like behaviors in animal models of human disease. Lastly, we consider ethical challenges in depression and anxiety research on NHPs in order to ultimately advance the understanding and the personalized treatment of these disorders.
抑郁症和焦虑症是人类中最普遍且使人衰弱的一些心理健康状况。它们可以单独出现，也可与其他疾病并存。与人类一样，非人灵长类动物（NHPs）也会出现类似抑郁和焦虑的症状。在此，我们首先定义人类的抑郁症和焦虑症，研究非人灵长类动物中类似的物种特异性行为，并探讨用于识别和评估这些行为的模型及当前方法。我们还讨论了知识空白，以及在人类疾病动物模型中评估类似抑郁和焦虑行为共现情况的重要性。最后，我们考虑了在非人灵长类动物抑郁症和焦虑症研究中的伦理挑战，以便最终增进对这些疾病的理解并实现个性化治疗。
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