Xu Qingqing, Fan Keliang, Wei Dandan, Wang Juan, Wang Xian, Lou Xiaomin, Lin Hualiang, Wang Chongjian, Wu Cuiping, Mao Zhenxing
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001 Henan People's Republic of China.
Teaching and Training Department, Affiliated Hospital of Jiaxing University/The First Hospital of Jiaxing, Zhejiang, 314000 China.
Z Gesundh Wiss. 2023 Jan 31:1-11. doi: 10.1007/s10389-023-01830-7.
With the launch of the COVID-19 vaccines, the vaccination rate has become a hot issue of concern. However, the evidence for the relationship between college students' attitudes toward vaccines and anxiety and depressive symptoms has been limited.
In total, 140,259 college students were recruited using a cluster sampling method in Zhengzhou, Xinxiang, Xinyang city of Henan Province, China, May 21-27, 2021. Anxiety symptoms were determined by the Generalized Anxiety Disorder tool (GAD-7) and depressive symptoms were determined by the Patient Health Questionnaire (PHQ-9). Multiple logistic regression was performed to estimate the association between students' attitudes toward the vaccines and anxiety and depressive symptoms.
The results indicate that 22.45% of students are unclear whether the vaccine can protect them from infection and 45.57% are unclear whether the vaccine is safe and has no side effects. In addition, after adjusting, the model showed that students who think vaccines can protect them and are safe had 0.128 (95%CI 0.110-0.150; P < 0.001) times lower risk of anxiety compared to their counterparts who think vaccines can neither protect them nor are safe. Similar ORs were found in depression (aOR = 0.157; 95%CI 0.137-0.180).
This large-scale study has shown an association between symptoms of anxiety and depression and reluctance to obtain vaccination.
The online version contains supplementary material available at 10.1007/s10389-023-01830-7.
随着新冠疫苗的推出，疫苗接种率已成为备受关注的热点问题。然而，关于大学生对疫苗的态度与焦虑和抑郁症状之间关系的证据有限。
2021年5月21日至27日，在中国河南省郑州市、新乡市、信阳市采用整群抽样方法共招募了140259名大学生。焦虑症状通过广泛性焦虑障碍工具（GAD-7）确定，抑郁症状通过患者健康问卷（PHQ-9）确定。进行多因素逻辑回归以估计学生对疫苗的态度与焦虑和抑郁症状之间的关联。
结果表明，22.45%的学生不清楚疫苗是否能保护他们免受感染，45.57%的学生不清楚疫苗是否安全且无副作用。此外，调整后模型显示，与认为疫苗既不能保护他们也不安全的学生相比，认为疫苗能保护他们且安全的学生焦虑风险降低了0.128倍（95%CI 0.110-0.150；P<0.001）。在抑郁方面也发现了类似的比值比（aOR = 0.157；95%CI 0.137-0.180）。
这项大规模研究表明焦虑和抑郁症状与不愿接种疫苗之间存在关联。
在线版本包含可在10.1007/s10389-023-01830-7获取的补充材料。
