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免疫细胞在椎间盘退变中的研究热点和趋势分析：文献计量研究。

Analysis of global research hotspots and trends in immune cells in intervertebral disc degeneration: A bibliometric study.

机构信息

Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, P.R. China.

Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing, China.

出版信息

Hum Vaccin Immunother. 2023 Dec 15;19(3):2274220. doi: 10.1080/21645515.2023.2274220. Epub 2023 Nov 9.

DOI:10.1080/21645515.2023.2274220
PMID:37941392
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10760394/
Abstract

Intervertebral disc degeneration is an important pathological basis for spinal degenerative diseases. The imbalance of the immune microenvironment and the involvement of immune cells has been shown to lead to nucleus pulposus cells death. This article presents a bibliometric analysis of studies on immune cells in IDD in order to clarify the current status and hotspots. We searched the WOSCC, Scopus and PubMed databases from 01/01/2001 to 08/03/2023. We analyzed and visualized the content using software such as Citespace, Vosviewer and the bibliometrix. This study found that the number of annual publications is increasing year on year. The journal study found that Spine had the highest number of articles and citations. The country/regions analysis showed that China had the highest number of publications, the USA had the highest number of citations and total link strength. The institutional analysis found that Shanghai Jiao Tong University and Huazhong University of Science Technology had the highest number of publications, Tokai University had the highest citations, and the University of Bern had the highest total link strength. Sakai D and Risbud MV had the highest number of publications. Sakai D had the highest total link strength, and Risbud MV had the highest number of citations. The results of the keyword analysis suggested that the current research hotspots and future directions continue to be the study of the mechanisms of immune cells in IDD, the therapeutic role of immune cells in IDD and the role of immune cells in tissue engineering for IDD.

摘要

椎间盘退变是脊柱退行性疾病的重要病理基础。免疫微环境失衡和免疫细胞的参与已被证明导致髓核细胞死亡。本文对椎间盘退变中免疫细胞的研究进行了文献计量学分析，以阐明其现状和热点。我们检索了 WOSCC、Scopus 和 PubMed 数据库，检索时间范围为 2001 年 1 月 1 日至 2023 年 8 月 3 日。我们使用 Citespace、Vosviewer 和 bibliometrix 等软件对内容进行分析和可视化。本研究发现，年度出版物数量逐年增加。期刊研究发现，Spine 杂志发表的文章和引用的文章数量最多。国家/地区分析显示，中国发表的文章数量最多，美国的引用数量和总链接强度最高。机构分析发现，上海交通大学和华中科技大学发表的文章数量最多，东海大学的引用数量最高，伯尔尼大学的总链接强度最高。Sakai D 和 Risbud MV 发表的文章数量最多。Sakai D 的总链接强度最高，Risbud MV 的引用数量最多。关键词分析的结果表明，目前的研究热点和未来的方向仍是免疫细胞在椎间盘退变中的作用机制、免疫细胞在椎间盘退变中的治疗作用以及免疫细胞在椎间盘退变组织工程中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/45d3272d0df5/KHVI_A_2274220_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/82f368822c7f/KHVI_A_2274220_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/7481fd5eb6bb/KHVI_A_2274220_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/e4dbbf96fc57/KHVI_A_2274220_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/8fa24910f047/KHVI_A_2274220_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/e7c29025d63c/KHVI_A_2274220_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/97e549f810a7/KHVI_A_2274220_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/4bc02bd0ffec/KHVI_A_2274220_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/45d3272d0df5/KHVI_A_2274220_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/82f368822c7f/KHVI_A_2274220_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/7481fd5eb6bb/KHVI_A_2274220_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/e4dbbf96fc57/KHVI_A_2274220_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/8fa24910f047/KHVI_A_2274220_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/e7c29025d63c/KHVI_A_2274220_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/97e549f810a7/KHVI_A_2274220_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/4bc02bd0ffec/KHVI_A_2274220_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f888/10760394/45d3272d0df5/KHVI_A_2274220_F0008_OC.jpg

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Analysis of global research hotspots and trends in immune cells in intervertebral disc degeneration: A bibliometric study.

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引用本文的文献

[1]
Immune microenvironment in intervertebral disc degeneration: pathophysiology and therapeutic potential.

Front Immunol. 2025-7-4

[2]
Trends and emerging frontiers of mesenchymal stem cells in intervertebral disc degeneration: a bibliometric analysis (2000-2024).

Front Med (Lausanne). 2025-6-25

[3]
The Role of Microvascular Variations in the Process of Intervertebral Disk Degeneration and Its Regulatory Mechanisms: A Literature Review.

Orthop Surg. 2024-11

本文引用的文献

[1]
Inhibition of PP2A ameliorates intervertebral disc degeneration by reducing annulus fibrosus cells apoptosis via p38/MAPK signal pathway.

Biochim Biophys Acta Mol Basis Dis. 2024-1

[2]
Panax notoginseng saponins inhibits oxidative stress- induced human nucleus pulposus cell apoptosis and delays disc degeneration in vivo and in vitro.

J Ethnopharmacol. 2024-1-30

[3]
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.

J Nanobiotechnology. 2023-9-4

[4]
Intervertebral disc degeneration and inflammatory microenvironment: expression, pathology, and therapeutic strategies.

Inflamm Res. 2023-9

[5]
The long non-coding RNA maternally expressed 3-micorRNA-15a-5p axis is modulated by melatonin and prevents nucleus pulposus cell inflammation and apoptosis.

Basic Clin Pharmacol Toxicol. 2023-11

[6]
Endoplasmic reticulum stress-mediated autophagy alleviates lipopolysaccharide-induced nucleus pulposus cell pyroptosis by inhibiting CHOP signaling in vitro.

J Biochem Mol Toxicol. 2024-1

[7]
Mechanisms of inhibition of nucleus pulposus cells pyroptosis through SDF1/CXCR4-NFkB-NLRP3 axis in the treatment of intervertebral disc degeneration by Duhuo Jisheng Decoction.

Int Immunopharmacol. 2023-11

[8]
A hydrogel reservoir as a self-contained nucleus pulposus cell delivery vehicle for immunoregulation and repair of degenerated intervertebral disc.

Acta Biomater. 2023-10-15

[9]
Screening of miR-15a-5p as a potential biomarker for intervertebral disc degeneration through RNA-sequencing.

Int Immunopharmacol. 2023-10

[10]
Roles of pyroptosis in intervertebral disc degeneration.

Pathol Res Pract. 2023-8

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