Professor of Plastic Surgery, University of Toledo College of Medicine and Life Sciences, and Jobst Vascular Institute, ProMedica Health Network, Toledo, Ohio, US.
J Wound Care. 2023 Jan 1;32(Sup1a):S3-S10. doi: 10.12968/jowc.2023.32.Sup1a.S3.
Advanced regenerative therapies using cellular and tissue-based products (CTPs) can play an important role in effective management of hard-to-heal wounds. CTPs derived from allogenic or xenogenic tissues use an extracellular matrix (ECM) to provide a therapeutic ECM scaffold in the wound bed to facilitate tissue regeneration. One such example is OASIS Extracellular Matrix (Cook Biotech Incorporated), a porcine small intestinal submucosa extracellular matrix (SIS-ECM) that preclinical and clinical data have shown to be tolerable and effective in promoting tissue regeneration in hard-to-heal wounds.
利用细胞和组织产品（CTPs）的先进再生疗法在有效管理难以愈合的伤口方面可以发挥重要作用。源自同种异体或异种组织的 CTP 利用细胞外基质（ECM）在伤口床中提供治疗性 ECM 支架，以促进组织再生。一个这样的例子是 OASIS 细胞外基质（库克生物技术公司），一种猪小肠黏膜下层细胞外基质（SIS-ECM），临床前和临床数据表明，它在促进难以愈合的伤口中的组织再生方面是耐受和有效的。
