Shi Lei, Ronfard Vincent
Smith & Nephew Fort Worth, TX, USA.
Int J Burns Trauma. 2013 Nov 1;3(4):173-9. eCollection 2013.
Porcine small intestinal submucosa (SIS [Oasis(®)]) is an acellular, biological extracellular matrix (ECM) that has been found to significantly improve the healing of difficult-to-heal or chronic wounds in humans. Like dermal ECM, SIS contains collagen, elastin, glycosaminoglycans, proteoglycans, and growth factors that play important roles in healing. Preclinical studies have shown that numerous cell types attach to SIS, proliferate and migrate into the matrix, and differentiate. In addition, SIS can reduce the activity of matrix metalloproteinases (MMPs)-endogenous proteolytic enzymes whose levels and activities are increased in chronic wounds. Compared to the original single-layer SIS, multi-layer SIS has stronger mechanical properties and is more slowly degraded in wounds. Together, these SIS products provide flexibility in the selection of biologically-active ECMs that may be useful for the repair of diverse wound types.
猪小肠黏膜下层（SIS [Oasis(®)]）是一种无细胞生物细胞外基质（ECM），已发现其能显著促进人类难愈合或慢性伤口的愈合。与真皮ECM一样，SIS含有胶原蛋白、弹性蛋白、糖胺聚糖、蛋白聚糖和在愈合过程中起重要作用的生长因子。临床前研究表明，多种细胞类型可附着于SIS，在基质中增殖、迁移并分化。此外，SIS可降低基质金属蛋白酶（MMPs）的活性，MMPs是内源性蛋白水解酶，其水平和活性在慢性伤口中会升高。与原始的单层SIS相比，多层SIS具有更强的机械性能，在伤口中的降解速度更慢。总之，这些SIS产品为选择可能对修复多种伤口类型有用的生物活性ECM提供了灵活性。
