利用秀丽隐杆线虫的遗传和基因组分析揭示记忆的新调控因子。
Uncovering novel regulators of memory using C. elegans genetic and genomic analysis.
机构信息
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, U.S.A.
Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX 77030, U.S.A.
出版信息
Biochem Soc Trans. 2023 Feb 27;51(1):161-171. doi: 10.1042/BST20220455.
How organisms learn and encode memory is an outstanding question in neuroscience research. Specifically, how memories are acquired and consolidated at the level of molecular and gene pathways remains unclear. In addition, memory is disrupted in a wide variety of neurological disorders; therefore, discovering molecular regulators of memory may reveal therapeutic targets for these disorders. C. elegans are an excellent model to uncover molecular and genetic regulators of memory. Indeed, the nematode's invariant neuronal lineage, fully mapped genome, and conserved associative behaviors have allowed the development of a breadth of genetic and genomic tools to examine learning and memory. In this mini-review, we discuss novel and exciting genetic and genomic techniques used to examine molecular and genetic underpinnings of memory from the level of the whole-worm to tissue-specific and cell-type specific approaches with high spatiotemporal resolution.
生物体如何学习和编码记忆是神经科学研究中的一个突出问题。具体来说，记忆是如何在分子和基因途径水平上获得和巩固的仍不清楚。此外，记忆在各种神经障碍中受到干扰；因此，发现记忆的分子调节剂可能为这些障碍揭示治疗靶点。秀丽隐杆线虫是揭示记忆的分子和遗传调节剂的极佳模型。事实上，线虫不变的神经元谱系、完全映射的基因组和保守的联想行为，使得开发了广泛的遗传和基因组工具来研究学习和记忆。在这篇迷你综述中，我们讨论了新颖而令人兴奋的遗传和基因组技术，用于从全虫水平到组织特异性和细胞类型特异性的方法，以高时空分辨率研究记忆的分子和遗传基础。
Zotero 插件