呼吸道合胞病毒和人偏肺病毒所致细支气管炎——流行病学、临床病程及预后：一家三级中心的经验

Bronchiolitis Due to RSV and HMPV-Epidemiology, Clinical Course, and Prognosis: Experience of a Single Tertiary Center.

作者信息

Azar Bar, Hashavya Saar, Ohana Sarna Cahan Lea, Reif Shimon, Gross Itai

机构信息

Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel.

Department of Pediatric Emergency Medicine, Hadassah Medical Center, Jerusalem, Israel.

出版信息

Clin Pediatr (Phila). 2023 Oct;62(9):1032-1039. doi: 10.1177/00099228231151401. Epub 2023 Feb 6.

DOI:10.1177/00099228231151401

PMID:36744682

Abstract

Acute bronchiolitis is a leading cause of hospitalization in infants. In this retrospective study, 645 patients with acute bronchiolitis diagnosed as respiratory syncytial virus (RSV; n = 538) or human metapneumovirus (HMPV; n = 107) were compared in terms of demographic, clinical, and laboratory findings. The HMPV patients presented later in the winter, were older (20 vs 7.55 months; < .001)), had higher levels of C-reactive protein (4.55 vs 3.03 mg/dL; = .007), and a higher prevalence of complications (43.9% vs 32.7%; = .03). This study highlights the similarities and differences between these 2 common respiratory viral pathogens and shows that HMPV has a slightly more severe disease course than RSV. These findings can help guide approaches to these 2 common viruses that cause bronchiolitis.

摘要

急性细支气管炎是婴儿住院的主要原因。在这项回顾性研究中，对645例诊断为呼吸道合胞病毒（RSV；n = 538）或人偏肺病毒（HMPV；n = 107）的急性细支气管炎患者的人口统计学、临床和实验室检查结果进行了比较。感染HMPV的患者在冬季较晚发病，年龄较大（20个月对7.55个月；P<0.001），C反应蛋白水平较高（4.55mg/dL对3.03mg/dL；P = 0.007），并发症发生率较高（43.9%对32.7%；P = 0.03）。本研究突出了这两种常见呼吸道病毒病原体之间的异同，表明HMPV导致的病程比RSV略为严重。这些发现有助于指导针对这两种引起细支气管炎的常见病毒的应对方法。