海洋海绵中两种新的萨拉西诺苷

Two new sarasinosides from marine sponge .

机构信息

Department of Chemistry, Mindanao State University-Iligan Institute of Technology, Iligan City, Philippines.

Premier Research Institute of Science and Mathematics, Mindanao State University-Iligan Institute of Technology, Iligan City, Philippines.

出版信息

Nat Prod Res. 2024 Jul;38(14):2395-2403. doi: 10.1080/14786419.2023.2175359. Epub 2023 Feb 6.

DOI:10.1080/14786419.2023.2175359

PMID:36744713

Abstract

Two new sarasinosides designated as 5,8-epoxysarasinoside () and 8,9-epoxysarasinoside () and four known sarasinosides were isolated from marine sponge , collected off the coast of Lipata, Surigao City, Philippines (9°49' North, 125°27' East). The structures were determined through extensive 2D NMR spectroscopy and HRMS. Both compounds exhibited low cytotoxicity against the HCT116 (colon) and A549 (lung) cancer cell lines.

摘要

从菲律宾苏里高市利帕塔（Lipata）海岸采集的海洋海绵中分离得到两种新的沙雷索苷，分别命名为 5,8-环氧沙雷索苷（）和 8,9-环氧沙雷索苷（），以及四种已知的沙雷索苷。通过广泛的二维 NMR 光谱和高分辨率质谱（HRMS）确定了这些化合物的结构。这两种化合物对 HCT116（结肠）和 A549（肺）癌细胞系均表现出较低的细胞毒性。