Department of Medical Imaging Sciences, Klintaps College of Health and Allied Sciences, Accra, DTD TDC, 30A Klagon, Com. 19, Tema, Ghana.
Clin Transl Oncol. 2023 Jul;25(7):1963-1976. doi: 10.1007/s12094-023-03100-0. Epub 2023 Feb 6.
Neutrophils have emerged as important players in the tumor microenvironment, largely attributed to their plasticity and heterogeneity. Evidence accumulated thus far indicates that neutrophils signaled by external cues can promote tumor progression via several mechanisms. Hence, in our quest to target tumor-associated neutrophils to improve treatment, understanding the mechanisms by which tumor-derived factors regulate neutrophils to gain pro-tumor functions and the feedback loop by which these neutrophils promote tumor progression is very crucial. Herein, we review the published data on how tumor-derived factors alter neutrophils phenotype to promote tumor progression with particular emphasis on immunosuppression, autophagy, angiogenesis, tumor proliferation, metastasis, and therapeutic resistance. These deeper insights could provide a wider view and novel therapeutic approach to neutrophil-targeted therapy in cancer.
中性粒细胞已成为肿瘤微环境中的重要参与者，这主要归因于它们的可塑性和异质性。迄今为止积累的证据表明，受外部信号刺激的中性粒细胞可通过多种机制促进肿瘤进展。因此，在我们寻求靶向肿瘤相关中性粒细胞以改善治疗的过程中，了解肿瘤衍生因子调节中性粒细胞获得促肿瘤功能的机制以及这些中性粒细胞促进肿瘤进展的反馈回路非常关键。本文综述了已发表的关于肿瘤衍生因子如何改变中性粒细胞表型以促进肿瘤进展的研究数据，特别强调了免疫抑制、自噬、血管生成、肿瘤增殖、转移和治疗抵抗。这些更深入的见解可以为癌症的中性粒细胞靶向治疗提供更广泛的视角和新的治疗方法。
