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解析中性粒细胞在淋巴瘤中的复杂作用：从发病机制到治疗方法（综述）

Unraveling the complex role of neutrophils in lymphoma: From pathogenesis to therapeutic approaches (Review).

作者信息

Wang Ke, Wang Xiao, Song Li

机构信息

Department of Cell Engineering, School of Life Sciences and Biotechnology, Sanquan College of Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.

Reproduction Medicine Center, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong 524002, P.R. China.

出版信息

Mol Clin Oncol. 2024 Sep 12;21(5):85. doi: 10.3892/mco.2024.2783. eCollection 2024 Nov.

DOI:10.3892/mco.2024.2783
PMID:39347476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11428085/
Abstract

Lymphoma, a malignancy of the lymphatic system, which is critical for maintaining the body's immune defenses, has become a focal point in recent research due to its intricate interplay with neutrophils-white blood cells essential for combating infections and inflammation. Unlike prior perceptions associating neutrophils only with tumor support, contemporary studies underscore their intricate and multifaceted involvement in the immune response to lymphoma. Recognizing the nuanced participation of neutrophils in lymphoma is crucial for developing innovative treatments to improve patient outcomes.

摘要

淋巴瘤是淋巴系统的一种恶性肿瘤，对维持人体免疫防御至关重要。由于它与中性粒细胞（对抗感染和炎症所必需的白细胞）之间存在复杂的相互作用，淋巴瘤已成为近期研究的焦点。与以往仅将中性粒细胞与肿瘤支持联系起来的观念不同，当代研究强调它们在对淋巴瘤的免疫反应中有着复杂而多方面的参与。认识到中性粒细胞在淋巴瘤中的细微参与对于开发创新疗法以改善患者预后至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7483/11428085/7bc2a028c98a/mco-21-05-02783-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7483/11428085/b61452c070ed/mco-21-05-02783-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7483/11428085/7bc2a028c98a/mco-21-05-02783-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7483/11428085/b61452c070ed/mco-21-05-02783-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7483/11428085/7bc2a028c98a/mco-21-05-02783-g01.jpg

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Cureus. 2024 May 22;16(5):e60854. doi: 10.7759/cureus.60854. eCollection 2024 May.
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METTL3 regulates M6A methylation-modified EBV-pri-miR-BART3-3p to promote NK/T cell lymphoma growth.METTL3 调控 M6A 甲基化修饰的 EBV-pri-miR-BART3-3p 促进 NK/T 细胞淋巴瘤生长。
Cancer Lett. 2024 Aug 10;597:217058. doi: 10.1016/j.canlet.2024.217058. Epub 2024 Jun 14.
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Neutrophils in Cancer immunotherapy: friends or foes?
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Mol Cancer. 2024 May 18;23(1):107. doi: 10.1186/s12943-024-02004-z.
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TRAF3 loss-of-function reveals the noncanonical NF-κB pathway as a therapeutic target in diffuse large B cell lymphoma.肿瘤坏死因子受体相关因子3功能缺失揭示非经典核因子κB信号通路可作为弥漫性大B细胞淋巴瘤的治疗靶点。
Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2320421121. doi: 10.1073/pnas.2320421121. Epub 2024 Apr 25.
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