人胎盘碱性磷酸酶基因及相关序列定位于2号染色体q37带。
The human placental alkaline phosphatase gene and related sequences map to chromosome 2 band q37.
作者信息
Martin D, Tucker D F, Gorman P, Sheer D, Spurr N K, Trowsdale J
机构信息
Imperial Cancer Research Fund, Lincoln's Inn Fields, London.
出版信息
Ann Hum Genet. 1987 May;51(2):145-52. doi: 10.1111/j.1469-1809.1987.tb01056.x.
A human placental alkaline phosphatase (PLAP) cDNA was isolated from a lambda gt 10 library of the cell line HEp-2. Southern blots probed with a fragment of the cDNA clone showed that the human genome may contain more than one PLAP-related sequence. The PLAP probe showed person-to-person variation in banding pattern with a number of enzymes. Using a panel of human/rodent somatic cell hybrids the PLAP sequences were mapped to chromosome 2. In situ hybridization confirmed this assignment and localized the gene(s) to chromosome 2 band q37.
从HEp - 2细胞系的λgt 10文库中分离出人类胎盘碱性磷酸酶（PLAP）cDNA。用该cDNA克隆片段进行Southern杂交，结果表明人类基因组可能包含多个与PLAP相关的序列。PLAP探针显示，与多种酶的条带模式存在个体差异。利用一组人/啮齿动物体细胞杂种，将PLAP序列定位到2号染色体。原位杂交证实了这一定位，并将该基因定位于2号染色体q37带。
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