人胎盘碱性磷酸酶基因和肠碱性磷酸酶基因定位于2q34 - q37。
Human placental and intestinal alkaline phosphatase genes map to 2q34-q37.
作者信息
Griffin C A, Smith M, Henthorn P S, Harris H, Weiss M J, Raducha M, Emanuel B S
机构信息
Department of Pediatrics, Children's Hospital of Philadelphia, PA 19104.
出版信息
Am J Hum Genet. 1987 Dec;41(6):1025-34.
Abstract
The alkaline phosphatases comprise a multigene enzyme family that hydolyze phosphate esters and are widely distributed in nature. Three main classes have been isolated from humans, the placental, intestinal, and liver/bone/kidney forms. We have mapped the placental and intestinal alkaline phosphatase genes to 2q34-q37 by using chromosomal in situ hybridization and a somatic-cell hybrid panel.
摘要
碱性磷酸酶构成了一个多基因酶家族，可水解磷酸酯，在自然界中广泛分布。已从人类中分离出三种主要类型，即胎盘型、肠型和肝/骨/肾型。我们通过使用染色体原位杂交和体细胞杂交板，将胎盘型和肠型碱性磷酸酶基因定位到了2q34 - q37。
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