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埃瑞莫霉素——一种来自环糖肽类的新型抗生素

[Eremomycin--a new antibiotic from the cyclic glycopeptide group].

作者信息

Gauze G F, Brazhnikova M G, Laĭko A V, Sveshnikova M A, Preobrazhenskaia T P

出版信息

Antibiot Med Biotekhnol. 1987 Aug;32(8):571-6.

PMID:3674837
Abstract

Eremomycin, a novel antibiotic belonging to the group of cyclic glycopeptides is produced by an actinomycete designated INA-238. Biosynthesis, isolation, physico-chemical and biological properties of the antibiotic are described. Eremomycin is shown to be close to vancomycin. However, by its chromatographic and electrophoretic mobility, presence of chlorine in the antibiotic molecule and optic characteristics eremomycin differs from vancomycin. Eremomycin is less toxic than vancomycin whereas its chemotherapeutic activity in treatment of infections caused by gram-positive organisms is higher.

摘要

埃瑞莫霉素是一种新型的环状糖肽类抗生素,由一株编号为INA - 238的放线菌产生。本文描述了该抗生素的生物合成、分离、理化性质及生物学特性。结果表明,埃瑞莫霉素与万古霉素相近。然而,通过色谱和电泳迁移率、抗生素分子中氯的存在以及光学特性,埃瑞莫霉素与万古霉素有所不同。埃瑞莫霉素的毒性低于万古霉素,而其对革兰氏阳性菌引起的感染的化疗活性更高。

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