头孢孟多与头孢呋辛对耐苯唑西林表皮葡萄球菌的活性及苯唑西林耐药表型之间的关系。
Relationship between cefamandole and cefuroxime activity against oxacillin-resistant Staphylococcus epidermidis and oxacillin resistance phenotype.
作者信息
Woods G L, Knapp C C, Washington J A
机构信息
Department of Microbiology, Cleveland Clinic Foundation, Ohio 44106.
出版信息
Antimicrob Agents Chemother. 1987 Sep;31(9):1332-7. doi: 10.1128/AAC.31.9.1332.
The activity of cefamandole and cefuroxime against oxacillin-resistant staphylococcus epidermidis was studied in vitro to determine whether there was any relationship between oxacillin resistance phenotypes and cephalosporin activity. Oxacillin resistance phenotypes were determined by efficiency-of-plating studies on Mueller-Hinton agar containing oxacillin, with and without NaCl, and incubated at 30 and 35 degrees C. On the basis of MIC and MBC determinations, cefamandole was more active than cefuroxime against oxacillin-resistant S. epidermidis. Although temperature had minimal effect on the activity of either cefamandole or cefuroxime, NaCl significantly decreased the activity of cefuroxime but not of cefamandole. Neither cephalosporin consistently produced greater than or equal to 99.9% bactericidal activity within 24 h in timed killing-curve studies. No consistent relationship was observed between cefamandole or cefuroxime activity and oxacillin resistance phenotype.
体外研究了头孢孟多和头孢呋辛对耐苯唑西林表皮葡萄球菌的活性，以确定苯唑西林耐药表型与头孢菌素活性之间是否存在任何关系。通过在含苯唑西林的穆勒-欣顿琼脂上进行接种效率研究来确定苯唑西林耐药表型，分别在有和没有氯化钠的情况下，于30℃和35℃孵育。基于最低抑菌浓度（MIC）和最低杀菌浓度（MBC）的测定，头孢孟多对耐苯唑西林表皮葡萄球菌的活性比头孢呋辛更强。尽管温度对头孢孟多或头孢呋辛的活性影响极小，但氯化钠显著降低了头孢呋辛的活性，而对头孢孟多没有影响。在定时杀菌曲线研究中，两种头孢菌素在24小时内均未持续产生大于或等于99.9%的杀菌活性。未观察到头孢孟多或头孢呋辛的活性与苯唑西林耐药表型之间存在一致的关系。
Zotero 插件